Risk factors and biomarkers of age-related macular degeneration

NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

Aflibercept: a review of its use in the treatment of choroidal neovascularization due to age-related macular degeneration

C Balaratnasingam, E Dhrami-Gavazi… - Clinical …, 2015 - Taylor & Francis
Choroidal neovascularization (CNV) due to age-related macular degeneration (AMD) is an
important cause of visual morbidity globally. Modern treatment strategies for neovascular …

Catalpol protects ARPE-19 cells against oxidative stress via activation of the Keap1/Nrf2/ARE pathway

L You, H Peng, J Liu, M Cai, H Wu, Z Zhang, J Bai… - Cells, 2021 - mdpi.com
Oxidative damage to retinal pigment epithelial (RPE) has been identified as one of the major
regulatory factors in the pathogenesis of age-related macular degeneration (AMD). Catalpol …

Association between CFH, CFB, ARMS2, SERPINF1, VEGFR1 and VEGF polymorphisms and anatomical and functional response to ranibizumab treatment in …

E Cobos, S Recalde, J Anter… - Acta …, 2018 - Wiley Online Library
Purpose We sought to determine if specific genetic single nucleotide polymorphisms (SNPs)
influence vascular endothelial growth factor inhibition response to ranibizumab in …

Association between polymorphisms in CFH, ARMS2, CFI, and C3 genes and response to anti-VEGF treatment in neovascular age-related macular degeneration

OS Kozhevnikova, AZ Fursova, AS Derbeneva… - Biomedicines, 2022 - mdpi.com
Neovascular age-related macular degeneration (nAMD) is the leading cause of vision loss
in the elderly. The gold standard of nAMD treatment is intravitreal injections of vascular …

Aflibercept administration in neovascular age-related macular degeneration refractory to previous anti-vascular endothelial growth factor drugs: a critical review and …

S Lazzeri, G Ripandelli, MS Sartini, M Parravano… - Angiogenesis, 2015 - Springer
Purpose The recent introduction of anti-VEGF drugs has widely changed the prognosis of
exudative age-related macular degeneration (AMD), even if a variable percentage of …

Anti-VEGF drugs influence epigenetic regulation and AMD-specific molecular markers in ARPE-19 cells

MA Hamid, MT Moustafa, S Nashine, RD Costa… - Cells, 2021 - mdpi.com
Our study assesses the effects of anti-VEGF (Vascular Endothelial Growth Factor) drugs and
Trichostatin A (TSA), an inhibitor of histone deacetylase (HDAC) activity, on cultured ARPE …

Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis

Y Zhou, C Chen, Y Wang, Y Tong, X Fang, L Li… - BMC …, 2017 - Springer
Background Anti-angiogenesis treatments are the most commonly used treatments for the
vision loss caused by exudative age-related macular degeneration (AMD), in which the anti …

Association of HTRA1 and ARMS2 gene polymorphisms with response to intravitreal ranibizumab among neovascular age-related macular degenerative subjects

NA Mohamad, V Ramachandran, H Mohd Isa… - Human Genomics, 2019 - Springer
Background The association of HTRA1 rs11200638 and ARMS2 rs10490924 gene
polymorphisms with response to intravitreal ranibizumab therapy among neovascular AMD …

Predictive genetics for AMD: Hype and hopes for genetics-based strategies for treatment and prevention

MB Gorin - Experimental eye research, 2020 - Elsevier
Age-related macular degeneration (AMD) is a complex disease with multiple genetic and
environmental risk factors. In the age of molecular genetics, many investigators have …