Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process
found in many malignant tumors, and is different from the traditional angiogenetic process …

Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of
human diseases including cancer. In this line, now it has become evident that ROS …

Simple Summary Hypoxia is defined as the inadequate supply of oxygen in tissues. Regions
of acute and chronic hypoxia are a universal feature of the tumor microenvironment and a …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

The transcription factor c-MYC (MYC thereafter) is a global regulator of gene expression. It is
overexpressed or deregulated in human cancers of diverse origins and plays a key role in …

Richter's Transformation (RT) is a poorly understood and fatal progression of chronic
lymphocytic leukemia (CLL) manifesting histologically as diffuse large B-cell lymphoma …