The gut microbiota and inflammation: an overview

Z Al Bander, MD Nitert, A Mousa… - International journal of …, 2020 - mdpi.com
The gut microbiota encompasses a diverse community of bacteria that carry out various
functions influencing the overall health of the host. These comprise nutrient metabolism …

[HTML][HTML] Gut microbiota: an important player in type 2 diabetes mellitus

Z Zhou, B Sun, D Yu, C Zhu - Frontiers in cellular and infection …, 2022 - frontiersin.org
Type 2 diabetes mellitus (T2DM) is one of the common metabolic diseases in the world. Due
to the rise in morbidity and mortality, it has become a global health problem. To date, T2DM …

Implication of trimethylamine N-oxide (TMAO) in disease: potential biomarker or new therapeutic target

MH Janeiro, MJ Ramírez, FI Milagro, JA Martínez… - Nutrients, 2018 - mdpi.com
Trimethylamine N-oxide (TMAO) is a molecule generated from choline, betaine, and
carnitine via gut microbial metabolism. The plasma level of TMAO is determined by several …

Uremic toxins in the progression of chronic kidney disease and cardiovascular disease: mechanisms and therapeutic targets

YJ Lim, NA Sidor, NC Tonial, A Che, BL Urquhart - Toxins, 2021 - mdpi.com
Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in
kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting …

[HTML][HTML] Trimethylamine N-oxide (TMAO) in human health

P Gatarek, J Kaluzna-Czaplinska - EXCLI journal, 2021 - ncbi.nlm.nih.gov
Due to numerous links between trimethylamine-N-oxide (TMAO) and various disorders and
diseases, this topic is very popular and is often taken up by researchers. TMAO is a low …

Gut microbiota and cardiovascular disease: opportunities and challenges

N Kazemian, M Mahmoudi, F Halperin, JC Wu… - Microbiome, 2020 - Springer
Coronary artery disease (CAD) is the most common health problem worldwide and remains
the leading cause of morbidity and mortality. Over the past decade, it has become clear that …

Dysbiosis of Gram-negative gut microbiota and the associated serum lipopolysaccharide exacerbates inflammation in type 2 diabetic patients with chronic kidney …

MV Salguero, MAI Al-Obaide… - Experimental and …, 2019 - spandidos-publications.com
Lipopolysaccharide (LPS), a potent endotoxin present in the outer membrane of Gram-
negative bacteria, causes chronic immune responses associated with inflammation. In the …

The gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

K Wu, Y Yuan, H Yu, X Dai, S Wang… - Blood, The Journal …, 2020 - ashpublications.org
The diversity of the human microbiome heralds the difference of the impact that gut microbial
metabolites exert on allogenic graft-versus-host (GVH) disease (GVHD), even though short …

Importance of gut microbiota metabolites in the development of cardiovascular diseases (CVD)

M Hemmati, S Kashanipoor, P Mazaheri, F Alibabaei… - Life Sciences, 2023 - Elsevier
Cardiovascular disease (CVD) remains the most common cause of death worldwide and
has become a public health concern. The proven notable risk factors for CVD are …

The relationship between choline bioavailability from diet, intestinal microbiota composition, and its modulation of human diseases

N Arias, S Arboleya, J Allison, A Kaliszewska… - Nutrients, 2020 - mdpi.com
Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of
choline results in the production of trimethylamine (TMA), which, upon absorption by the host …