Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

INTRODUCTION Skin wounds generally heal by scarring, a fibrotic process mediated by the
Engrailed-1 (En1) fibroblast lineage. Scars differ from normal unwounded skin in three …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

Excessive extracellular matrix deposition drives fibroblasts into a state of high mechanical
stress, exacerbating pathological fibrosis and hypertrophic scar formation, leading to tissue …

Regeneration is the holy grail of tissue repair, but skin injury typically yields fibrotic, non-
functional scars. Developing pro-regenerative therapies requires rigorous understanding of …

Fibroblasts are cells present throughout the human body that are primarily responsible for
the production and maintenance of the extracellular matrix (ECM) within the tissues. They …

Bioprinting techniques have been flourishing in the field of biofabrication with pronounced
and exponential developments in the past years. Novel biomaterial inks used for the …

Skin wound dressings are commonly used to stimulate and enhance skin tissue repair. Even
if wounds seem easy to repair for clinicians and to replicate in an in vitro set-up for scientists …