Importance of resting heart rate

B Olshansky, F Ricci, A Fedorowski - Trends in Cardiovascular Medicine, 2023 - Elsevier
Resting heart rate is a determinant of cardiac output and physiological homeostasis.
Although a simple, but critical, parameter, this vital sign predicts adverse outcomes …

Genetics of sinoatrial node function and heart rate disorders

LE van der Maarel, AV Postma… - Disease models & …, 2023 - journals.biologists.com
The sinoatrial node (SAN) is the primary pacemaker of the mammalian heart, initiating its
electrical activation and ensuring that the heart's functional cardiac output meets …

Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness

M Bäck, C Xhaard, R Rouget, Q Thuillier… - … Heart Journal Open, 2022 - academic.oup.com
Aims Long-chain polyunsaturated fatty acids (PUFAs) generate diverse bioactive lipid
mediators, which tightly regulate vascular inflammation. The effects of omega-3 PUFA …

Layer myocardial strain is the most heritable echocardiographic trait

O Huttin, C Xhaard, C Dandine-Roulland… - European Heart …, 2023 - academic.oup.com
Aims Myocardial deformation assessed by strain analysis represents a significant
advancement in our assessment of cardiac mechanics. However, whether this variable is …

Association between heart rate and major adverse cardiovascular events among 9,991 hypertentive patients: a multicenter retrospective follow-up study

N Sun, Y Chen, Y Xi, H Wang, L Wang - Frontiers in Cardiovascular …, 2021 - frontiersin.org
Objective: To assess the effect of heart rate at baseline on major adverse cardiovascular
events (MACEs) among hypertensive patients in China. Methods: A multicenter retrospective …

Birth weight and subclinical cardiovascular and renal damage in a population-based study (the STANISLAS cohort study)

M Lopez-Sublet, T Merkling, N Girerd… - Journal of …, 2023 - journals.lww.com
Objective: Although preterm-born and low-birth-weight individuals have an increased risk of
cardiovascular diseases in adulthood, little is known regarding early cardiovascular and …

Single cell multi-omics of an iPSC model of human sinoatrial node development reveals genetic determinants of heart rate and arrhythmia susceptibility

JL Engel, X Zhang, DR Lu, OF Vila, V Arias, J Lee… - bioRxiv, 2023 - biorxiv.org
Defining the molecular and genetic basis for heart rate regulation and for susceptibility to
atrial arrhythmias has been challenging due to the complexity of the human sinoatrial node …

Circulating plasma proteins and new-onset diabetes in a population-based study: proteomic and genomic insights from the STANISLAS cohort

JP Ferreira, Z Lamiral, C Xhaard… - European Journal of …, 2020 - academic.oup.com
Objective Determining the factors associated with new-onset pre-diabetes and type 2
diabetes mellitus (T2D) is important for improving the current prevention strategies and for a …

Multiomic profiling of new-onset kidney function decline: insights from the STANISLAS study cohort with a 20-year follow-up

V Dupont, C Xhaard, I Behm-Ansmant… - Clinical Kidney …, 2024 - academic.oup.com
Background Identifying the biomarkers associated with new-onset glomerular filtration rate
(GFR) decrease in an initially healthy population could offer a better understanding of kidney …

Associations between physical activity and autonomic function during deep breathing test: the Swedish CArdioPulmonary bioImage Study (SCAPIS)

E Memarian, I Kharraziha, V Hamrefors… - Clinical Autonomic …, 2023 - Springer
Purpose The deep breathing test (DBT) is a sensitive test of cardiovagal function. The aim of
this study was to explore associations between physical activity and sedentary time …