Roles of pyridine and pyrimidine derivatives as privileged scaffolds in anticancer agents
S Prachayasittikul, R Pingaew… - Mini Reviews in …, 2017 - ingentaconnect.com
Background: Cancer has been considered to be a global health concern due to the impact of
disease on the quality of life. The continual increase of cancer cases as well as the …
disease on the quality of life. The continual increase of cancer cases as well as the …
Fused and substituted pyrimidine derivatives as profound anti-cancer agents
N Abbas, GSP Matada, PS Dhiwar… - Anti-Cancer Agents …, 2021 - ingentaconnect.com
The rationale behind drug design is the strategic utilization of heterocyclic fragments with
specific physicochemical properties to form molecular targeted agents. Among the …
specific physicochemical properties to form molecular targeted agents. Among the …
Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4 (3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis …
HA Mahdy, MK Ibrahim, AM Metwaly, A Belal… - Bioorganic …, 2020 - Elsevier
Inhibiting VEGFR-2 has been set up as a therapeutic strategy for treatment of cancer.
Accordingly, new quinazoline-based derivatives having the structural features of VEGFR-2 …
Accordingly, new quinazoline-based derivatives having the structural features of VEGFR-2 …
Benzoxazole/benzothiazole‐derived VEGFR‐2 inhibitors: design, synthesis, molecular docking, and anticancer evaluations
AGA El‐Helby, H Sakr, IH Eissa… - Archiv der …, 2019 - Wiley Online Library
A novel series of benzoxazole/benzothiazole derivatives 4a–c–11a–e were designed,
synthesized, and evaluated for anticancer activity against HepG2, HCT‐116, and MCF‐7 …
synthesized, and evaluated for anticancer activity against HepG2, HCT‐116, and MCF‐7 …
Design and synthesis of new 1, 6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation
Abstract A series of new 1, 6-dihydropyrimidin-2-thiol derivatives (scaffold A) as VEGFR-2
inhibitors has been designed and synthesized. Compounds 3a, 3b, 3e and 4b have been …
inhibitors has been designed and synthesized. Compounds 3a, 3b, 3e and 4b have been …
Synthesis and investigation of the conversion reactions of pyrimidine‐thiones with nucleophilic reagent and evaluation of their acetylcholinesterase, carbonic …
The conversion reactions of pyrimidine‐thiones with nucleophilic reagent were studied
during this scientific research. For this purpose, new compounds were synthesized by the …
during this scientific research. For this purpose, new compounds were synthesized by the …
Synthesis, characterization, antioxidant, antidiabetic, anticholinergic, and antiepileptic properties of novel N‐substituted tetrahydropyrimidines based on …
In the presence of trifluoroacetic acid, on the basis of three‐component condensation of
phenylthiourea with its salicylaldehyde and methyl‐3‐oxobutanoate, an efficient method for …
phenylthiourea with its salicylaldehyde and methyl‐3‐oxobutanoate, an efficient method for …
Novel indolyl-pyrimidine derivatives: synthesis, antimicrobial, and antioxidant evaluations
MS Mohamed, MM Youns, NM Ahmed - Medicinal Chemistry Research, 2014 - Springer
In the present study, a novel series of indolyl-pyrimidines (1–13) were synthesized starting
from 4-hydrazinopyrimidine-5-carbonitrile 3. Elemental analysis, IR, 1 H-NMR, 13 C-NMR …
from 4-hydrazinopyrimidine-5-carbonitrile 3. Elemental analysis, IR, 1 H-NMR, 13 C-NMR …
Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and …
Thiouracil and thiocytosine are important heterocyclic pharmacophores having
pharmacological diversity. Antitumor and antiviral activity is commonly associated with …
pharmacological diversity. Antitumor and antiviral activity is commonly associated with …
A modified approach for the site-selective direct C-6 arylation of benzylated uracil
An efficient methodology is reported for the regioselective C-6 arylation of protected uracil
via the palladium catalyzed Csingle bondH functionalization of 1-(4-methoxybenzyl)-3 …
via the palladium catalyzed Csingle bondH functionalization of 1-(4-methoxybenzyl)-3 …