The midcycle surge of LH sets in motion interconnected networks of signaling cascades to
bring about rupture of the follicle and release of the oocyte during ovulation. Many mediators …

High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is
the most common and deadliest type of ovarian cancer. HGSC appears to arise from the …

The cell-of-origin of high grade serous ovarian carcinoma (HGSOC) remains controversial,
with fallopian tube epithelium (FTE) and ovarian surface epithelium (OSE) both considered …

Malignant ascites presents a considerable clinical challenge to the management of ovarian
cancer, but also provides a wealth of opportunities for translational research. The …

Background Accurate identification of ovarian cancer (OC) is of paramount importance in
clinical treatment success. Artificial intelligence (AI) is a potentially reliable assistant for the …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

The objective of this study was to identify and characterize a self-renewing subpopulation of
human ovarian tumor cells (ovarian cancer-initiating cells, OCICs) fully capable of serial …

Historically, research in ovarian biology has focused on folliculogenesis, but recently the
ovarian stroma has become an exciting new frontier for research, holding critical keys to …

The cellular mechanisms underlying the increasing aggressiveness associated with ovarian
cancer progression are poorly understood. Coupled with a lack of identification of specific …

Using molecular, cellular, and genetic approaches, recent studies examining the role of the
bone morphogenetic protein (BMP) family of growth factors in the reproductive system have …