Molecular mechanism of HIV-1 entry

B Chen - Trends in microbiology, 2019 - cell.com
HIV-1 envelope glycoprotein [Env; trimeric (gp160) 3 cleaved to (gp120/gp41) 3] attaches
the virion to a susceptible cell and induces fusion of viral and cell membranes to initiate …

Targeting CCR5 as a component of an HIV-1 therapeutic strategy

H Mohamed, T Gurrola, R Berman, M Collins… - Frontiers in …, 2022 - frontiersin.org
Globally, human immunodeficiency virus type 1 (HIV-1) infection is a major health burden for
which successful therapeutic options are still being investigated. Challenges facing current …

Structural basis of coreceptor recognition by HIV-1 envelope spike

MM Shaik, H Peng, J Lu, S Rits-Volloch, C Xu, M Liao… - Nature, 2019 - nature.com
Abstract HIV-1 envelope glycoprotein (Env), which consists of trimeric (gp160) 3 cleaved to
(gp120 and gp41) 3, interacts with the primary receptor CD4 and a coreceptor (such as …

Protein–protein interactions in virus–host systems

AF Brito, JW Pinney - Frontiers in microbiology, 2017 - frontiersin.org
To study virus–host protein interactions, knowledge about viral and host protein
architectures and repertoires, their particular evolutionary mechanisms, and information on …

Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies

I Kufareva, CL Salanga… - Immunology and cell …, 2015 - Wiley Online Library
The control of cell migration by chemokines involves interactions with two types of receptors:
seven transmembrane chemokine‐type G protein‐coupled receptors and cell surface or …

Interactions between curcumin derivatives and amyloid-β fibrils: insights from molecular dynamics simulations

JM Jakubowski, AA Orr, DA Le… - Journal of chemical …, 2019 - ACS Publications
The aggregation of amyloid-β (Aβ) peptides into senile plaques is a hallmark of Alzheimer's
disease (AD) and is hypothesized to be the primary cause of AD related neurodegeneration …

Mapping interaction sites on human chemokine receptors by deep mutational scanning

JD Heredia, J Park, RJ Brubaker… - The Journal of …, 2018 - journals.aai.org
Chemokine receptors CXCR4 and CCR5 regulate WBC trafficking and are engaged by the
HIV-1 envelope glycoprotein gp120 during infection. We combine a selection of human …

Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same clade

H Song, W Ou, Y Feng, J Zhang, F Li… - Proceedings of the …, 2019 - National Acad Sciences
HIV-1 evolved into various genetic subtypes and circulating recombinant forms (CRFs) in the
global epidemic. The same subtype or CRF is usually considered to have similar phenotype …

Mechanisms underlying of antiretroviral drugs in different cellular reservoirs with a focus on macrophages

S Aquaro, A Borrajo, M Pellegrino, V Svicher - Virulence, 2020 - Taylor & Francis
Ongoing with current combinations of antiretroviral drugs for the treatment of Human
Immunodeficiency Virus (HIV) infection can successfully maintain long-term suppression of …

Editor's highlight: Microbial-derived 1, 4-dihydroxy-2-naphthoic acid and related compounds as aryl hydrocarbon receptor agonists/antagonists: Structure–activity …

Y Cheng, UH Jin, LA Davidson… - Toxicological …, 2017 - academic.oup.com
1, 4-Dihydroxy-2-naphthoic acid (1, 4-DHNA) is a bacterial-derived metabolite that binds the
aryl hydrocarbon receptor (AhR) and exhibits anti-inflammatory activity in the gut. The …