The progress and promise of RNA medicine─ an arsenal of targeted treatments

JM Sasso, BJB Ambrose, R Tenchov… - Journal of medicinal …, 2022 - ACS Publications
In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …

Promising biomarkers of human aging: In search of a multi-omics panel to understand the aging process from a multidimensional perspective

NA Rivero-Segura, OY Bello-Chavolla… - Ageing research …, 2020 - Elsevier
The aging process has been linked to the occurrence of chronic diseases and functional
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …

The biogenesis and biological function of PIWI-interacting RNA in cancer

S Chen, S Ben, J Xin, S Li, R Zheng, H Wang… - Journal of hematology & …, 2021 - Springer
Small non-coding RNAs (ncRNAs) are vital regulators of biological activities, and aberrant
levels of small ncRNAs are commonly found in precancerous lesions and cancer. PIWI …

Transposable elements and human diseases: mechanisms and implication in the response to environmental pollutants

B Chénais - International journal of molecular sciences, 2022 - mdpi.com
Transposable elements (TEs) are recognized as major players in genome plasticity and
evolution. The high abundance of TEs in the human genome, especially the Alu and Long …

Molecular crosstalk between cancer and neurodegenerative diseases

J Seo, M Park - Cellular and Molecular Life Sciences, 2020 - Springer
The progression of cancers and neurodegenerative disorders is largely defined by a set of
molecular determinants that are either complementarily deregulated, or share remarkably …

Type I interferons and related pathways in cell senescence

SM Frisch, IP MacFawn - Aging cell, 2020 - Wiley Online Library
This review article addresses the largely unanticipated convergence of two landmark
discoveries. The first is the discovery of interferons, critical signaling molecules for all …

Non-coding RNAs: Emerging from the discovery to therapeutic applications

B Baptista, M Riscado, JA Queiroz, C Pichon… - Biochemical …, 2021 - Elsevier
The knowledge about non-coding RNAs (ncRNAs) is rapidly increasing with new data
continuously emerging, regarding their diverse types, applications, and roles. Particular …

Transposable elements and their role in aging

E Yushkova, A Moskalev - Ageing Research Reviews, 2023 - Elsevier
Transposable elements (TEs) are an important part of eukaryotic genomes. The role of
somatic transposition in aging, carcinogenesis, and other age-related diseases has been …

Emerging roles of PIWI-interacting RNAs (piRNAs) and PIWI proteins in head and neck cancer and their potential clinical implications

T Chattopadhyay, P Biswal, A Lalruatfela… - Biochimica et Biophysica …, 2022 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) are among the well-known neoplasms
originating in the oral cavity, pharynx, and larynx. Despite advancements in chemotherapy …

Proteomic analysis from skin swabs reveals a new set of proteins identifying skin impairment in atopic dermatitis

P Morelli, M Gaspari, C Gabriele… - Experimental …, 2021 - Wiley Online Library
Atopic Dermatitis (AD) is a common inflammatory skin disease characterized by skin and
systemic inflammation, and barrier dysfunction. Herein, we investigate the proteomic profile …