The endoplasmic reticulum is an important intracellular organelle that plays an important
role in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) and unfolded …

The polo-like kinases (Plks) encompass a family of five serine/threonine protein kinases that
play essential roles in many cellular processes involved in the control of the cell cycle …

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic
activity of asparagine synthetase (ASNS). While ASNS and asparagine have been …

Conclusions Our study demonstrates a mixed fibrinolytic phenotype in acutely ill patients
with cirrhosis with baseline hypofibrinolysis associated with sepsis, organ failure, and short …

Chronic inflammation increases the risk of developing one of several types of cancer.
Inflammatory responses are currently thought to be controlled by mechanisms that rely on …

Brazil has one of the fastest-growing COVID-19 epidemics worldwide. Non-pharmaceutical
interventions (NPIs) have been adopted at the municipal level with asynchronous actions …

Background and Aims Hepatic endoplasmic reticulum (ER) stress, whether triggered by
intrinsic or extrinsic factors, can be resolved by the unfolded protein response (UPR) …

The unfolded protein response (UPR) improves endoplasmic reticulum (ER) protein folding
in order to alleviate stress. Yet it is becoming increasingly clear that the UPR regulates …

Various tumors develop addiction to glutamine to support uncontrolled cell proliferation.
Here we identify the nuclear receptor liver receptor homolog 1 (LRH-1) as a key regulator in …

Acute hepatic injury is observed in response to various stressors, including trauma,
ingestion of hepatic toxins, and hepatitis. Investigations to date have focused on extrinsic …