The generation of B lymphocytes from hematopoietic progenitors requires lineage-specific
transcription factors that progressively direct cell fate choices. Differentiation of …

A widely accepted paradigm in cancer research holds that the development of cancers is
rate limited by the occurrence of oncogenic mutations. In particular, the exponential rise in …

Ikaros transcription factors are essential for adaptive lymphocyte function, yet their role in
innate lymphopoiesis is unknown. Using conditional genetic inactivation, we show that …

Leukemias exhibit a dysregulated developmental program mediated through both genetic
and epigenetic mechanisms. Although IKZF2 is expressed in hematopoietic stem cells …

Deletions in IKZF1 are found in~ 15% of children with B-cell precursor acute lymphoblastic
leukemia (BCP-ALL). There is strong evidence for the poor prognosis of IKZF1 deletions …

Background Deletions of IKAROS (IKZF1) frequently occur in B-cell precursor acute
lymphoblastic leukemia (B-ALL) but the mechanisms by which they influence pathogenesis …

The physiologic roles of angiopoietin-like proteins (Angptls) in the hematopoietic system
remain unknown. Here we show that hematopoietic stem cells (HSCs) in Angptl3-null mice …

Genomic analyses estimated that the proportion of the genome encoding proteins
corresponds to approximately 1.5%, while at least 66% are transcribed, suggesting that …

Current research suggests that a number of newly identified T‐helper cell subsets retain a
degree of context‐dependent plasticity in their signature cytokine expression patterns. To …

The thymus is seeded by bone marrow-derived progenitors, which undergo a series of
differentiation and proliferation events in order to generate functional T lymphocytes. The …