Benzodiazepines and medications acting on benzodiazepine receptors that do not have a
benzodiazepine structure (z-drugs) have been viewed by some experts and regulatory …

Purpose The case‐crossover design is a self‐controlled study design used to compare
exposure immediately preceding an event occurrence with exposure in earlier control …

Objective To study the factors associated with opioid use and potentially inappropriate
opioid use (PIOU) in primary care older adults with non‐cancer pain referring to the …

Introduction: In 2019, Scotland reported the highest number of drug deaths amongst EU
countries. Of the 1,264 drug deaths reported in 2019, 94% were related to polysedative use …

The prescription of strong opioids (SO) for chronic non-cancer pain (CNCP) is steadily
increasing. This entails a high risk of adverse effects, a risk that increases with the …

Background Pre-injury opioid use is common, but the effects of opioid-related polysubstance
use on mortality and health resources utilization (HRU) have not been investigated yet. The …

Background: Impact of immeasurable time bias (IMTB) is yet to be examined in self-
controlled designs. Methods: We conducted case-crossover, case-time-control, and case …

Background Opioid misuse constitutes a health care crisis in Canada, and coprescription of
opioids with sedatives has been associated with adverse events. Opioids and sedatives are …

Badania i doświadczenie kliniczne z ostatnich lat przyczyniły się do ogromnego postępu w
leczeniu bólu przewlekłego lekami opioidowymi. Udowodniono, że leczenie to może być …

[cat] INTRODUCCIÓ: La prescripció d'Opioides Forts (OF) és cada cop més habitual a les
consultes d'Atenció Primària (AP) de Catalunya, amb un augment sostingut de la DHD …