Programmed cell death pathways and current antitumor targets

ML Tan, JP Ooi, N Ismail, AIH Moad… - Pharmaceutical …, 2009 - Springer
Apoptosis and autophagic cell deaths are programmed cell deaths and they play essential
roles in cell survival, growth and development and tumorigenesis. The huge increase of …

In vitro antioxidant and antiproliferative potential of medicinal plants used in traditional Indian medicine to treat cancer

AA Baskar, KS Al. Numair, MA Alsaif, S Ignacimuthu - redox Report, 2012 - Taylor & Francis
Objective The goal of this study was to evaluate the antioxidant and antiproliferative
activities of 10 traditional medicinal plants, Asclepias curassavica, Ophiorrhiza mungos …

Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia

LW Chan, ELC Cheah, CLL Saw, W Weng… - Chinese Medicine, 2008 - Springer
Background Eight medicinal plants were tested for their antimicrobial and antioxidant
activities. Different extraction methods were also tested for their effects on the bioactivities of …

A review on plant-derived immunomodulatory agents: Hopes as an alternative medicine in the management of immune-related disorders

KD Deva, BV Bose, D Basavan - Traditional and …, 2023 - publish.kne-publishing.com
In humans, the immune system serves as a protective barrier against infection; however,
when the immune system is out of balance, it can harm the host. Immunomodulators are …

Clausenidin induces caspase-dependent apoptosis in colon cancer

PM Waziri, R Abdullah, SK Yeap, AR Omar… - … and alternative medicine, 2016 - Springer
Abstract Background Clausena excavata Burm. f. is a shrub traditionally used to treat cancer
patients in Asia. The main bioactive chemical components of the plant are alkaloids and …

C13 Megastigmane Derivatives From Epipremnum pinnatum: β-Damascenone Inhibits the Expression of Pro-Inflammatory Cytokines and Leukocyte Adhesion …

SP Pan, T Pirker, O Kunert, N Kretschmer… - Frontiers in …, 2019 - frontiersin.org
In order to identify active constituents and to gain some information regarding their mode of
action, extracts from leaves of Epipremnum pinnatum were tested for their ability to inhibit …

Cytotoxic Activities of Major Diterpenoid Constituents of Andrographis paniculata. in a Panel of Human Tumor Cell Lines

ML Tan, M Kuroyanagi, SF Sulaiman… - Pharmaceutical …, 2005 - Taylor & Francis
The cytotoxic activities of several diterpenoid constituents of the medicinal plant,“hempedu
bumi,” or Andrographis paniculata. Nees (Acanthaceae), were evaluated. The seven …

Autophagy is induced by 3β-O-succinyl-lupeol (LD9-4) in A549 cells via up-regulation of Beclin 1 and down-regulation mTOR pathway

J Hao, Y Pei, G Ji, W Li, S Feng, S Qiu - European journal of pharmacology, 2011 - Elsevier
The purpose of this study is to investigate the antitumor activity of a new derivative of lupeol-
3β-O-succinyl-lupeol (LD9-4) and the molecular mechanism underlying cell death in human …

Cytotoxic and apoptotic effects of ethyl acetate extract of Elephantopus mollis Kunth. In human liver carcinoma HepG2 cells through caspase-3 activation

KL Ooi, TS Tengku Muhammad… - Integrative Cancer …, 2014 - journals.sagepub.com
Previous cytotoxic (anticancer) evaluations of Elephantopus mollis were mainly focused on
its elephantopin derivatives neglecting the combined effect of the phytochemicals in its …

Induction of apoptosis against cancer cell lines by four ascomycetes (endophytes) from Malaysian rainforest

NAMN Hazalin, K Ramasamy, SM Lim, ALJ Cole… - Phytomedicine, 2012 - Elsevier
Endophytic fungi have been shown to be a promising source of biologically active natural
products. In the present study, extracts of four endophytic fungi isolated from plants of the …