Clinical significance of hepatitis C virus genotypes

NN Zein - Clinical microbiology reviews, 2000 - Am Soc Microbiol
On the basis of phylogenetic analysis of nucleotide sequences, multiple genotypes and
subtypes of hepatitis C virus (HCV) have been identified. Characterization of these genetic …

Hepatitis C: the clinical spectrum of disease

JH Hoofnagle - Hepatology, 1997 - journals.lww.com
Hepatitis C virus (HCV) accounts for approximately 20% of cases of acute hepatitis, 70% of
chronic hepatitis, and 30% of end-stage liver disease in the United States. The acute …

Estimating progression to cirrhosis in chronic hepatitis C virus infection

AJ Freeman, GJ Dore, MG Law, M Thorpe… - Hepatology, 2001 - journals.lww.com
To gain a clearer understanding of the rate of progression to cirrhosis and its determinants in
chronic hepatitis C virus (HCV) infection, a systematic review of published epidemiologic …

Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

N Enomoto, I Sakuma, Y Asahina… - … England Journal of …, 1996 - Mass Medical Soc
Background A region associated with sensitivity to interferon has been identified in the
nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) genotype 1b. The region spans …

[PDF][PDF] Prognosis of chronic hepatitis C: results of a large, prospective cohort study

C Niederau, S Lange, T Heintges, A Erhardt… - …, 1998 - Wiley Online Library
The prognosis of chronic hepatitis C virus (HCV) infection is still ill‐defined. The present
study prospectively evaluated mortality and complications in a large cohort of patients with …

Impact of alcohol on the histological and clinical progression of hepatitis C infection

TE Wiley, M McCarthy, L Breidi, M McCarthy… - Hepatology, 1998 - journals.lww.com
In patients infected with the hepatitis C virus (HCV), 20% to 30% will progress to cirrhosis in
over two to three decades. Viral and host factors that are important in the clinical and …

Hepatitis C: the clinical spectrum of the disease

P Marcellin - Journal of hepatology, 1999 - Elsevier
The hepatitis C virus (HCV) infects nearly 170 million people worldwide and is responsible
for approximately 20% of cases of acute hepatitis and 70% of cases of chronic hepatitis …

Hepatitis C virus genotype 1b as a risk factor for hepatocellular carcinoma development: a meta-analysis

S Raimondi, S Bruno, MU Mondelli… - Journal of hepatology, 2009 - Elsevier
BACKGROUND/AIMS: Hepatitis C virus (HCV) is a known risk factor for hepatocellular
carcinoma (HCC), but whether the risk varies among patients infected with different HCV …

Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C

A Kasahara, N Hayashi, K Mochizuki, M Takayanagi… - Hepatology, 1998 - journals.lww.com
To elucidate the risk factors for liver carcinogenesis and to examine the incidence of
hepatocellular carcinoma (HCC) after interferon therapy, 1,022 chronic hepatitis C patients …

Prevalence, risk factors, and genotype distribution of hepatitis C virus infection in the general population: a community-based survey in southern Italy

V Guadagnino, T Stroffolini, M Rapicetta… - Hepatology, 1997 - journals.lww.com
In 1996 the prevalence, risk factors, and genotype distribution of hepatitis C virus (HCV)
infection were assessed in the general population of a town in southern Italy. The sample …