Over the past 15 years there has been an explosion of research on the dynamical properties
of proteins, largely driven by the emergence of a handful of techniques that are sensitive to …

Life at the molecular level is a dynamic world, where the key players─ proteins,
oligonucleotides, lipids, and carbohydrates─ are in a perpetual state of structural flux …

A method is presented for the determination of values of the spectral density function, J (ω),
describing the dynamics of amide bond vectors from 15 N relaxation parameters alone …

Two-dimensional NMR 15N relaxation studies have been used to characterize the
backbone dynamics and folding transition of the N-terminal SH3 domain of the protein drk …

NMR spectroscopy is a powerful approach for quantitating molecular conformational
dynamics at multiple atomic sites and over multiple time scales. Extensive studies by …

Revised Manuscript Received October 12, 1995® abstract: The internal mobility of the
protein eglin c is characterized with spectral density functions of the NH vectors obtained …

Revised Manuscript Received December 13, 1994® abstract: Spectral density functions 7
(0), 7 (con), and 7 (coh+ c^ n) of individual amide N-15 nuclei in proteins were approximated …

FK506 (tacrolimus) is a natural product now approved in the US and Japan for organ
transplantation. FK506, in complex with its 12 kDa cytosolic receptor (FKBP12), is a potent …

The solution structure of the demetalated copper, zinc superoxide dismutase is obtained for
the monomeric Glu133Gln/Phe50Glu/Gly51Glu mutant through NMR spectroscopy. The …

Recent developments in Nuclear Magnetic Resonance spectroscopy (NMR) have had a
significant impact on solution structural studies of proteins (Clore and Gronenborn, 1991; …