Since the original publication describing the illness in 1907, the genetic understanding of
Alzheimer's disease (AD) has advanced such that it is now clear that it is a genetically …

Abstract The Brain and Body Donation Program (BBDP) at Banner Sun Health Research
Institute (http://www. brainandbodydonationprogram. org) started in 1987 with brain-only …

Brain changes associated with Alzheimer's disease (AD) begin decades before disease
diagnosis. While β-amyloid plaques and neurofibrillary tangles are defining features of AD …

The RNA‐like endoplasmic reticulum kinase (PERK) is genetically associated with the
tauopathy progressive supranuclear palsy (PSP). To elucidate the functional mechanisms …

Alzheimer's disease (AD) is the most common cause of dementia, characterized by
progressive loss of cognitive function, with β-amyloid plaques and neurofibrillary tangles …

Background: Clinicopathological studies have demonstrated that Alzheimer's disease
dementia (ADD) is often accompanied by clinically undetectable comorbid …

Studying comorbidities in early onset Alzheimer disease (AD) may provide an advantageous
perspective on their pathogenesis because aging factors may be largely inoperative for …

We sought to determine the associations among cerebral amyloid angiopathy (CAA), white
matter rarefaction (WMR), circle of Willis atherosclerosis (CWA), and total microinfarct …

Years of intensive research has brought us extensive knowledge on the genetic and
molecular factors involved in Alzheimer's disease (AD). In addition to the mutations in the …

The mechanisms underlying presenilin 1 (PSEN1) mutation–associated spastic paraparesis
(SP) are not clear. We compared diffusion and volumetric magnetic resonance measures …