The role of tumor microenvironment in chemoresistance: to survive, keep your enemies closer

DA Senthebane, A Rowe, NE Thomford… - International journal of …, 2017 - mdpi.com
Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to
be a challenge in cancer treatment. Chemoresistance is influenced by genetic and …

Caveolin‐1, cancer and therapy resistance

J Ketteler, D Klein - International journal of cancer, 2018 - Wiley Online Library
Resistance of solid tumors to chemo‐and radiotherapy remains a major obstacle in anti‐
cancer treatment. Herein, the membrane protein caveolin‐1 (CAV1) came into focus as it is …

Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies distinct proteotypes associated with patient outcomes

S Mirhadi, S Tam, Q Li, N Moghal, NA Pham… - Nature …, 2022 - nature.com
Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. Only
a fraction of NSCLC harbor actionable driver mutations and there is an urgent need for …

[HTML][HTML] Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer

L Simón, A Campos, L Leyton, AFG Quest - Cancer and Metastasis …, 2020 - Springer
Abstract Caveolin-1 (CAV1) is commonly considered to function as a cell surface protein, for
instance in the genesis of caveolae. Nonetheless, it is also present in many intracellular …

Research trends and hotspots on the links between caveolin and cancer: bibliometric and visual analysis from 2003 to 2022

Y Tan, Q Song - Frontiers in Pharmacology, 2023 - frontiersin.org
Introduction: Extensive studies indicated that caveolin is a key regulator in multiple cellular
processes. Recently, growing evidence demonstrated that caveolin is critically involved in …

Cell intrinsic and extrinsic mechanisms of caveolin-1-enhanced metastasis

A Campos, R Burgos-Ravanal, MF González… - Biomolecules, 2019 - mdpi.com
Caveolin-1 (CAV1) is a scaffolding protein with a controversial role in cancer. This review
will initially discuss earlier studies focused on the role as a tumor suppressor before …

Tyrosine phosphorylation of tumor cell caveolin-1: impact on cancer progression

TH Wong, FH Dickson, LR Timmins, IR Nabi - Cancer and Metastasis …, 2020 - Springer
Abstract Caveolin-1 (CAV1) has long been implicated in cancer progression, and while
widely accepted as an oncogenic protein, CAV1 also has tumor suppressor activity. CAV1 …

Thy-1 (CD90)-Induced Metastatic Cancer Cell Migration and Invasion Are β3 Integrin-Dependent and Involve a Ca2+/P2X7 Receptor Signaling Axis

M Brenet, S Martínez, R Pérez-Nuñez… - Frontiers in Cell and …, 2021 - frontiersin.org
Cancer cell adhesion to the vascular endothelium is an important step in tumor metastasis.
Thy-1 (CD90), a cell adhesion molecule expressed in activated endothelial cells, has been …

Design of a biodegradable UV-irradiated gelatin-chitosan/nanocomposed membrane with osteogenic ability for application in bone regeneration

CA Acevedo, Y Olguín, M Briceño, JC Forero… - Materials Science and …, 2019 - Elsevier
Guided bone regeneration membranes are used in oral surgery to protect the site of a lesion
exposed to connective tissue invasion which, in turn, prevents new bone formation. Although …

Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response

MI Díaz, P Díaz, JC Bennett, H Urra, R Ortiz… - Cell death & …, 2020 - nature.com
Abstract Caveolin-1 (CAV1), is a broadly expressed, membrane-associated scaffolding
protein that acts both, as a tumor suppressor and a promoter of metastasis, depending on …