The amyloid cascade hypothesis: an updated critical review
Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …
disease have created excitement and have been heralded as corroboration of the amyloid …
The genetic landscape of Alzheimer disease: clinical implications and perspectives
C Van Cauwenberghe, C Van Broeckhoven… - Genetics in …, 2016 - nature.com
The search for the genetic factors contributing to Alzheimer disease (AD) has evolved
tremendously throughout the years. It started from the discovery of fully penetrant mutations …
tremendously throughout the years. It started from the discovery of fully penetrant mutations …
Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers
Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …
Interactions of pathological proteins in neurodegenerative diseases
Neurodegenerative diseases such as Alzheimer's disease (AD), frontotemporal lobar
degeneration (FTD), Lewy body disease (LBD), Parkinson's disease (PD), and amyotrophic …
degeneration (FTD), Lewy body disease (LBD), Parkinson's disease (PD), and amyotrophic …
[HTML][HTML] Molecular genetics of early-onset Alzheimer's disease revisited
R Cacace, K Sleegers, C Van Broeckhoven - Alzheimer's & dementia, 2016 - Elsevier
As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in
families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD …
families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD …
A large panel of isogenic APP and PSEN1 mutant human iPSC neurons reveals shared endosomal abnormalities mediated by APP β-CTFs, not Aβ
D Kwart, A Gregg, C Scheckel, EA Murphy, D Paquet… - Neuron, 2019 - cell.com
Familial Alzheimer's disease (fAD) results from mutations in the amyloid precursor protein
(APP) and presenilin (PSEN1 and PSEN2) genes. Here we leveraged recent advances in …
(APP) and presenilin (PSEN1 and PSEN2) genes. Here we leveraged recent advances in …
Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies
Abnormal deposition of misprocessed and aggregated proteins is a common final pathway
of most neurodegenerative diseases, including Alzheimer's disease (AD). AD is …
of most neurodegenerative diseases, including Alzheimer's disease (AD). AD is …
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
EH Corder, AM Saunders, WJ Strittmatter… - Science, 1993 - science.org
The apolipoprotein E type 4 allele (APOE-ε4) is genetically associated with the common late
onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from …
onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from …
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
AM Saunders, WJ Strittmatter, D Schmechel… - Neurology, 1993 - AAN Enterprises
Apolipoprotein E, type ϵ4 allele (APOE ϵ4), is associated with late-onset familial
Alzheimer's disease (AD). There is high avidity and specific binding of amyloid β-peptide …
Alzheimer's disease (AD). There is high avidity and specific binding of amyloid β-peptide …
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
R Sherrington, EI Rogaev, Y Liang, EA Rogaeva… - Nature, 1995 - nature.com
Some cases of Alzheimer's disease are inherited as an autosomal dominant trait. Genetic
linkage studies have mapped a locus (AD3) associated with susceptibility to a very …
linkage studies have mapped a locus (AD3) associated with susceptibility to a very …