The protein inhibitor of activated STAT (PIAS) family of proteins has been proposed to
regulate the activity of many transcription factors, including signal transducer and activator of …

SUMOylation is a ubiquitination‐like post‐translational modification that plays an essential
role in the regulation of protein function. Recent studies have shown that proteins from both …

Host defense systems employ posttranslational modifications to protect against invading
pathogens. Here, we found that protein inhibitor of activated STAT 1 (PIAS1) interacts with …

SUMO modifications regulate the function of many proteins and are important in controlling
herpesvirus infections. We performed a site-specific proteomic analysis of SUMO1-and …

Since posttranslational modification (PTM) by the small ubiquitin-related modifiers (SUMOs)
was discovered over a decade ago, a huge number of cellular proteins have been found to …

Herpesviruses are large, ubiquitous DNA viruses with complex host interactions, yet many of
the proteins encoded by these viruses have not been functionally characterized. As a first …

Activation of interferon regulatory factors (IRFs) 3 and 7 is essential for the induction of Type
I interferons (IFN) and innate antiviral responses, and herpesviruses have evolved …

Viruses exploit various cellular processes for their own benefit, including counteracting anti-
viral responses and regulating viral replication and propagation. In the past 20 years, protein …

Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes a highly basic
nucleocapsid (N) protein of 422 amino acids. Similar to other coronavirus N proteins, SARS …

Since its discovery in 1997, SUMO (small ubiquitin-like modifier) has been implicated in a
range of activities, indicating that this protein is as important in the cell as ubiquitin is …