Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

Ceramide synthases (CerS) are key enzymes in the lipid metabolism of eukaryotic cells.
Their products, ceramides (Cer), are components of cellular membranes but also mediate …

Purpose Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy. Up
till now, the patient's prognosis remains poor which, among others, is due to the paucity of …

Breast cancer (BC) leads to the highest mortality in women worldwide, characterized by
inevitable proliferation and metastasis of BC cells. Mounting evidence confirm that lncRNAs …

MicroRNAs (miRNAs) are small noncoding RNAs that could regulate gene expressions
transcriptionally or post-transcriptionally through binding to 3'untranslated region (3'UTR) of …

Mechanistic details for the roles of sphingolipids and their downstream targets in the
regulation of tumor growth, response to chemo/radiotherapy, and metastasis have been …

Simple Summary Brain metastasis is common in patients with non-small cell lung cancer
and is associated with a poor prognosis. Ceramide synthase 1 participates in malignancy …

Resveratrol is a naturally occurring polyphenol which has various beneficial effects, such as
anti-inflammatory, anti-tumor, anti-aging, antioxidant, and neuroprotective effects, among …

Purpose: Regulated in development and DNA damage response-1 (REDD1) is a stress-
related protein and is involved in the progression of cancer. The role and regulatory …

Melatonin has been reported to have tumor-suppressive effects via comprehensive
molecular mechanisms, and long non-coding RNAs (lncRNAs) may participate in this …