Control of satellite cell function in muscle regeneration and its disruption in ageing

P Sousa-Victor, L García-Prat… - … Reviews Molecular Cell …, 2022 - nature.com
Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

A de Morree, TA Rando - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Single-cell analysis of the muscle stem cell hierarchy identifies heterotypic communication signals involved in skeletal muscle regeneration

AJ De Micheli, EJ Laurilliard, CL Heinke… - Cell reports, 2020 - cell.com
Muscle regeneration relies on the regulation of muscle stem cells (MuSCs) through
paracrine signaling interactions. We analyzed muscle regeneration in mice using single-cell …

Adult stem cells at work: regenerating skeletal muscle

M Schmidt, SC Schüler, SS Hüttner, B von Eyss… - Cellular and Molecular …, 2019 - Springer
Skeletal muscle regeneration is a finely tuned process involving the activation of various
cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are …

[PDF][PDF] Satellite cells and skeletal muscle regeneration

NA Dumont, CF Bentzinger, MC Sincennes… - Compr …, 2015 - researchgate.net
Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

Muscle satellite cell cross-talk with a vascular niche maintains quiescence via VEGF and notch signaling

M Verma, Y Asakura, BSR Murakonda, T Pengo… - Cell stem cell, 2018 - cell.com
Skeletal muscle is a complex tissue containing tissue resident muscle stem cells (satellite
cells)(MuSCs) important for postnatal muscle growth and regeneration. Quantitative analysis …

Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division

NA Dumont, YX Wang, J Von Maltzahn, A Pasut… - Nature medicine, 2015 - nature.com
Dystrophin is expressed in differentiated myofibers, in which it is required for sarcolemmal
integrity, and loss-of-function mutations in the gene that encodes it result in Duchenne …

Intrinsic and extrinsic mechanisms regulating satellite cell function

NA Dumont, YX Wang, MA Rudnicki - Development, 2015 - journals.biologists.com
Muscle stem cells, termed satellite cells, are crucial for skeletal muscle growth and
regeneration. In healthy adult muscle, satellite cells are quiescent but poised for activation …

The central role of muscle stem cells in regenerative failure with aging

HM Blau, BD Cosgrove, ATV Ho - Nature medicine, 2015 - nature.com
Skeletal muscle mass, function, and repair capacity all progressively decline with aging,
restricting mobility, voluntary function, and quality of life. Skeletal muscle repair is facilitated …

Orienting muscle stem cells for regeneration in homeostasis, aging, and disease

P Feige, CE Brun, M Ritso, MA Rudnicki - Cell stem cell, 2018 - cell.com
Muscle stem cells, or satellite cells, are required for skeletal muscle maintenance, growth,
and repair. Following satellite cell activation, several factors drive asymmetric cell division to …