Continuous proliferation of tumor cells requires constant adaptations of energy metabolism
to rapidly fuel cell growth and division. This energetic adaptation often comprises …

Metabolic reprogramming in tumours is now recognized as a hallmark of cancer,
participating both in tumour growth and cancer progression. Cancer cells develop global …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

It is not clear to what extent starvation-induced autophagy affects the proteome on a global
scale and whether it is selective. In this study, we report based on quantitative proteomics …

Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of metabolic
and nutrient cues that integrates environmental inputs into downstream signaling pathways …

The mechanistic target of rapamycin complex 1 (mTORC1), a multi-subunit protein kinase
complex, interrogates growth factor signaling with cellular nutrient and energy status to …

Triple-negative breast cancer (TNBC) is highly heterogeneous and has a poor prognosis. It
is therefore important to identify the underlying molecular mechanisms in order to develop …

Autophagy, a lysosomal catabolic process, involves degradation of cellular materials,
protein aggregate, and dysfunctional organelles to maintain cellular homeostasis. Strikingly …

Foam cells are lipid-laden macrophages that contribute to the inflammation and tissue
damage associated with many chronic inflammatory disorders. Although foam cell …