The “first hit” toward alcohol reinforcement: role of ethanol metabolites

Y Israel, ME Quintanilla, E Karahanian… - Alcoholism: Clinical …, 2015 - Wiley Online Library
This review analyzes literature that describes the behavioral effects of 2 metabolites of
ethanol (EtOH): acetaldehyde and salsolinol (a condensation product of acetaldehyde and …

The impact of caffeine on the behavioral effects of ethanol related to abuse and addiction: a review of animal studies

L López-Cruz, JD Salamone… - Journal of caffeine …, 2013 - liebertpub.com
The impact of caffeine on the behavioral effects of ethanol, including ethanol consumption
and abuse, has become a topic of great interest due to the rise in popularity of the so-called …

Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids

Y Gao, Z Zhou, T Ren, SJ Kim, Y He, W Seo, A Guillot… - Gut, 2019 - gut.bmj.com
Objective Aldehyde dehydrogenase 2 (ALDH2), a key enzyme to detoxify acetaldehyde in
the liver, exists in both active and inactive forms in humans. Individuals with inactive ALDH2 …

Characterizing the scent and chemical composition of Panthera leo marking fluid using solid-phase microextraction and multidimensional gas chromatography–mass …

SB Soso, JA Koziel - Scientific Reports, 2017 - nature.com
Lions (Panthera leo) use chemical signaling to indicate health, reproductive status, and
territorial ownership. To date, no study has reported on both scent and composition of …

Key role of salsolinol in ethanol actions on dopamine neuronal activity of the posterior ventral tegmental area

M Melis, E Carboni, P Caboni, E Acquas - Addiction biology, 2015 - Wiley Online Library
Ethanol excites dopamine (DA) neurons in the posterior ventral tegmental area (pVTA). This
effect is responsible for ethanol's motivational properties and may contribute to alcoholism …

Acute and chronic alcohol administration: effects on performance of zebrafish in a latent learning task

AC Luchiari, DC Salajan, R Gerlai - Behavioural brain research, 2015 - Elsevier
Alcohol abuse is a major medical problem. Zebrafish have been proposed to model alcohol
related human disorders. Alcohol impairs learning and memory. Here, we analyze the …

Acetaldehyde self-administration by a two-bottle choice paradigm: consequences on emotional reactivity, spatial learning, and memory

F Plescia, A Brancato, M Venniro, G Maniaci… - Alcohol, 2015 - Elsevier
Acetaldehyde, the first alcohol metabolite, is responsible for many pharmacological effects
that are not clearly distinguishable from those exerted by its parent compound. It alters motor …

Acetate as an active metabolite of ethanol: studies of locomotion, loss of righting reflex, and anxiety in rodents

M Pardo, AJ Betz, N San Miguel… - Frontiers in behavioral …, 2013 - frontiersin.org
It has been postulated that a number of the central effects of ethanol are mediated via
ethanol metabolites: acetaldehyde and acetate. Ethanol is known to produce a large variety …

Behavioral consequences of the downstream products of ethanol metabolism involved in alcohol use disorder

OT Holbrook, B Molligoda, KN Bushell… - … & Biobehavioral Reviews, 2022 - Elsevier
Abstract Research concerning Alcohol Use Disorder (AUD) has previously focused primarily
on either the behavioral or chemical consequences experienced following ethanol intake …

Síndrome de abstinencia alcohólica: Resultado del estrés oxidativo y desequilibrio neuronal. Estado del arte

MTD Soto, JMC Miranda - Revista Biomédica, 2020 - dialnet.unirioja.es
El alcoholismo constituye una enfermedad crónica que conlleva a afectaciones
conductuales que se prolongan durante la abstinencia. El consumo de etanol incrementa la …