Evidence implicating Eph receptor tyrosine kinases and their ephrin ligands (that together
make up the 'Eph system') in cancer development and progression has been accumulating …

Vasculogenic mimicry (VM) is a blood supply system independent of endothelial vessels in
tumor cells from different origins. It reflects the plasticity of aggressive tumor cells that …

Glioblastoma multiforme (GBM) is an incurable form of brain cancer with a very poor
prognosis. Because of its highly invasive nature, it is impossible to remove all tumor cells …

Glioblastoma multiforme (GBM) is the most common and lethal cancer of the adult brain,
remaining incurable with a median survival time of only 15 months. In an effort to identify …

In human glioblastomas (hGBMs), tumor-propagating cells with stem-like characteristics
(TPCs) represent a key therapeutic target. We found that the EphA2 receptor tyrosine kinase …

Angiogenesis and vasculogenic mimicry (VM) are thought to be the predominant processes
ensuring tumor blood supply during the growth and metastasis of glioblastoma (GBM) …

Tumor cell vasculogenic mimicry (VM), also dubbed vascular mimicry, describes the
plasticity of aggressive cancer cells forming de novo vascular networks and is associated …

Accumulating evidence has implied that microRNAs (miRNAs) are implicated in glioma
progression, and genetically engineered mesenchymal stem cells can help to inhibit tumor …

Malignant brain tumors rank among the most challenging type of malignancies to manage.
The current treatment protocol commonly entails surgery followed by radiotherapy and/or …

Glioblastoma multiforme (GBM) is an aggressive grade IV astrocytoma with a 1-year median
survival rate despite current treatment modalities. A thorough understanding of the vast …