Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Ursolic acid (UA) is a natural terpene compound exhibiting many pharmaceutical properties.
In this review the current state of knowledge about the health-promoting properties of this …

Simple Summary Mutations in the tumor suppressor p53 (p53) occur in~ 50% of human
cancers, the majority of which are missense mutations. Mutations in p53 not only impair the …

Maintenance of phenotypic heterogeneity within cell populations is an evolutionarily
conserved mechanism that underlies population survival upon stressful exposures. We …

Long interspersed nuclear element-1 (LINE-1) retrotransposition is a major hallmark of
cancer accompanied by global chromosomal instability, genomic instability, and genetic …

Human endogenous retroviruses (HERVs) comprise nearly 8% of the human genome and
are derived from ancient integrations of retroviruses into the germline. The biology of HERVs …

LINE-1 (L1) retrotransposons make up a significant portion of human genomes, with an
estimated 500,000 copies per genome. Like other retrotransposons, L1 retrotransposons …

The use of anti-HIV drugs as cancer treatments is not new. Azidothymidine was studied as
an antineoplastic in the 1990s, but despite promising in vitro data, clinical trials showed little …

Medulloblastoma is the most common malignant tumor of central nervous system in children.
Patients affected by medulloblastoma may be categorized as high-risk and standard-risk …