Comprehensive review and empirical analysis of hallmarks of DNA-, RNA-and protein-binding residues in protein chains
Proteins interact with a variety of molecules including proteins and nucleic acids. We review
a comprehensive collection of over 50 studies that analyze and/or predict these interactions …
a comprehensive collection of over 50 studies that analyze and/or predict these interactions …
Designing template-free predictor for targeting protein-ligand binding sites with classifier ensemble and spatial clustering
Accurately identifying the protein-ligand binding sites or pockets is of significant importance
for both protein function analysis and drug design. Although much progress has been made …
for both protein function analysis and drug design. Although much progress has been made …
Elucidating important structural features for the binding affinity of spike‐SARS‐CoV‐2 neutralizing antibody complexes
Abstract The coronavirus disease 2019 (COVID‐19) has affected the lives of millions of
people around the world. In an effort to develop therapeutic interventions and control the …
people around the world. In an effort to develop therapeutic interventions and control the …
Protein-protein interactions and prediction: a comprehensive overview
G Sowmya, S Ranganathan - Protein and peptide letters, 2014 - ingentaconnect.com
Molecular function in cellular processes is governed by protein-protein interactions (PPIs)
within biological networks. Selective yet specific association of these protein partners …
within biological networks. Selective yet specific association of these protein partners …
DeepBSRPred: Deep learning-based binding site residue prediction for proteins
Abstract Motivation Proteins–protein interactions (PPIs) are important to govern several
cellular activities. Amino acid residues, which are located at the interface are known as the …
cellular activities. Amino acid residues, which are located at the interface are known as the …
DNAgenie: accurate prediction of DNA-type-specific binding residues in protein sequences
Efforts to elucidate protein–DNA interactions at the molecular level rely in part on accurate
predictions of DNA-binding residues in protein sequences. While there are over a dozen …
predictions of DNA-binding residues in protein sequences. While there are over a dozen …
A new supervised over-sampling algorithm with application to protein-nucleotide binding residue prediction
Protein-nucleotide interactions are ubiquitous in a wide variety of biological processes.
Accurately identifying interaction residues solely from protein sequences is useful for both …
Accurately identifying interaction residues solely from protein sequences is useful for both …
Feature selection and classification of protein–protein complexes based on their binding affinities using machine learning approaches
K Yugandhar, MM Gromiha - Proteins: Structure, Function, and …, 2014 - Wiley Online Library
Protein–protein interactions are intrinsic to virtually every cellular process. Predicting the
binding affinity of protein–protein complexes is one of the challenging problems in …
binding affinity of protein–protein complexes is one of the challenging problems in …
Studying macromolecular complex stoichiometries by peptide‐based mass spectrometry
A majority of cellular functions are carried out by macromolecular complexes. A host of
biochemical and spectroscopic methods exists to characterize especially protein/protein …
biochemical and spectroscopic methods exists to characterize especially protein/protein …
Energetics and dynamics across the Bcl-2-regulated apoptotic pathway reveal distinct evolutionary determinants of specificity and affinity
Critical regulatory pathways are replete with instances of intra-and interfamily protein-protein
interactions due to the pervasiveness of gene duplication throughout evolution. Discerning …
interactions due to the pervasiveness of gene duplication throughout evolution. Discerning …