Fasciolosis in South America: epidemiology and control challenges

C Carmona, JF Tort - Journal of helminthology, 2017 - cambridge.org
Fasciolosis caused by Fasciola hepatica severely affects the efficiency of livestock
production systems worldwide. In addition to the economic impact inflicted on livestock …

The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica: Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis*[S]

K Cwiklinski, E de la Torre-Escudero, M Trelis… - Molecular & Cellular …, 2015 - ASBMB
Extracellular vesicles (EVs) released by parasites have important roles in establishing and
maintaining infection. Analysis of the soluble and vesicular secretions of adult Fasciola …

[HTML][HTML] Fasciola hepatica vaccine: we may not be there yet but we're on the right road

V Molina-Hernández, G Mulcahy, J Pérez… - Veterinary …, 2015 - Elsevier
Major advances have been made in identifying potential vaccine molecules for the control of
fasciolosis in livestock but we have yet to reach the level of efficacy required for …

Csi-let-7a-5p delivered by extracellular vesicles from a liver fluke activates M1-like macrophages and exacerbates biliary injuries

C Yan, QY Zhou, J Wu, N Xu, Y Du… - Proceedings of the …, 2021 - National Acad Sciences
Chronic infection with liver flukes (such as Clonorchis sinensis) can induce severe biliary
injuries, which can cause cholangitis, biliary fibrosis, and even cholangiocarcinoma. The …

Functional genomics tools for Haemonchus contortus and lessons from other helminths

C Britton, B Roberts, ND Marks - Advances in parasitology, 2016 - Elsevier
The availability of genome and transcriptome data for parasitic nematodes, including
Haemonchus contortus, has highlighted the need to develop functional genomics tools …

Anthelmintic Potential of Thymoquinone and Curcumin on Fasciola gigantica

R Ullah, A Rehman, MF Zafeer, L Rehman, YA Khan… - PloS one, 2017 - journals.plos.org
Fasciolosis an economically important global disease of ruminants in the temperate and
tropical regions, caused by Fasciola hepatica and F. gigantica, respectively, also poses a …

A trematode parasite derived growth factor binds and exerts influences on host immune functions via host cytokine receptor complexes

AA Sulaiman, K Zolnierczyk, O Japa, JP Owen… - PLoS …, 2016 - journals.plos.org
The trematode Fasciola hepatica is responsible for chronic zoonotic infection globally.
Despite causing a potent T-helper 2 response, it is believed that potent immunomodulation …

Galactokinase deficiency: lessons from the GalNet registry

ME Rubio-Gozalbo, B Derks, AM Das, U Meyer… - Genetics in …, 2021 - nature.com
Purpose Galactokinase (GALK1) deficiency is a rare hereditary galactose metabolism
disorder. Beyond cataract, the phenotypic spectrum is questionable. Data from affected …

Stimulating Neoblast-Like Cell Proliferation in Juvenile Fasciola hepatica Supports Growth and Progression towards the Adult Phenotype In Vitro

P McCusker, P McVeigh, V Rathinasamy… - PLoS neglected …, 2016 - journals.plos.org
Fascioliasis (or fasciolosis) is a socioeconomically important parasitic disease caused by
liver flukes of the genus Fasciola. Flukicide resistance has exposed the need for new drugs …

Diversity of extracellular vesicles from different developmental stages of Fasciola hepatica

CM Sánchez-López, M Trelis, L Jara… - International Journal for …, 2020 - Elsevier
The secretion of extracellular vesicles (EVs) in Fasciola hepatica adult worms was described
by our group in 2012. Since then, EVs have been found in other helminths, thus providing a …