Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous
system. Over the past decade, our understanding of this disease has advanced …

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

Purpose Because current approaches to risk classification and treatment stratification for
children with neuroblastoma (NB) vary greatly throughout the world, it is difficult to directly …

Neuroblastoma (NB) is one of the most common forms of cancer in children, accounting for
15% of pediatric cancer deaths. The clinical course of these tumors is highly variable and is …

Neuroblastoma serves as a paradigm for utilising tumour genomic data for determining
patient prognosis and treatment allocation. However, before the establishment of the …

Aberrant epigenetic changes in DNA methylation and histone acetylation are hallmarks of
most cancers, whereas histone methylation was previously considered to be irreversible and …

Purpose: Activating mutations of the anaplastic lymphoma kinase (ALK) were recently
described in neuroblastoma. We carried out a meta-analysis of 709 neuroblastoma tumors …

Purpose For a comprehensive overview of the genetic alterations of neuroblastoma, their
association and clinical significance, we conducted a whole-genome DNA copy number …

Purpose The primary objective of Children's Oncology Group study P9641 was to
demonstrate that surgery alone would achieve 3-year overall survival (OS)≥ 95% for …

Neuroblastoma accounts for 15% of pediatric cancer deaths, and although a few protein-
coding genes, such as MYCN, are involved with aggressive pathogenicity, the identification …