The GATA family of transcription factors is of crucial importance during embryonic
development, playing complex and widespread roles in cell fate decisions and tissue …

Tissue homeostasis requires the presence of multipotent adult stem cells that are capable of
efficient self-renewal and differentiation; some of these have been shown to exist in a …

The zinc-finger transcription factor GATA-3 has received much attention as a master
regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4) …

The activity of adult stem cells is regulated by signals emanating from the surrounding
tissue. Many niche signals have been identified, but it is unclear how they influence the …

GATA3 has conventionally been regarded as a transcription factor that drives the
differentiation of T helper (Th) 2 cells. Increasing evidence points to a function for GATA3 …

Early innate lymphoid progenitors (EILPs) have recently been identified in mouse adult bone
marrow as a multipotential progenitor population specified toward innate lymphoid cell (ILC) …

T cells show tremendous efficacy as cellular therapeutics. However, obtaining primary T
cells from human donors is expensive and variable. Pluripotent stem cells (PSCs) have the …

GATA3 is a transcription factor critical for embryogenesis, development, and cell
differentiation. Recent studies have suggested that GATA3 is a sensitive and relatively …

The transcription factor GATA-2 plays vital roles in quite diverse developmental programs,
including hematopoietic stem cell (HSC) survival and proliferation. We previously identified …

Fusion genes involving MEF2D have recently been identified in precursor B-cell acute
lymphoblastic leukemia, mutually exclusive of the common risk stratifying genetic …