The versatility of immunoassays for the detection of antigens can be combined with the
signal amplification power of nucleic acid amplification techniques in a broad range of …

Prion diseases are usually diagnosed clinically and confirmed by post-mortem
histopathological examination of brain tissue. The only reliable molecular marker for prion …

There is increasing concern over the extent to which bovine spongiform encephalopathy
(BSE) prions have been transmitted to humans, as a result of the rising number of variant …

Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative prion disease
affecting cattle that is transmissible to humans, manifesting as a variant of Creutzfeldt-Jakob …

Prion diseases are among the most intriguing infectious diseases and are associated with
unconventional proteinaceous infectious agents known as prions. Prions seem to lack …

Taking an interdisciplinary approach that emphasizes the adaptability of immunochemical
and related bioanalytical methods to a variety of matrices, Immunoassay and Other …

Pathologic prion protein (PrPSc), implicated in transmissible spongiform encephalopathies,
is detected by antibody-based tests or bioassays to confirm the diagnosis of prion diseases …

Sensitive quantitation of prions in biological samples is an extremely important and
challenging analytical problem. Prions are the cause of several fatal neurodegenerative …

The molecular diagnosis of prion diseases almost always involves the use of a protease to
distinguish PrP C from PrP Sc and invariably the protease of choice is proteinase K. Here …

Clinical criteria for the diagnosis of sporadic, iatrogenic and variant Creutzfeldt–Jakob
diseases are now available and show an excellent sensitivity and specificity (∼ 98%). Post …