The Wnt/β-catenin signaling pathway is a classical Wnt pathway that regulates the stability
and nuclear localization of β-catenin and plays an important role in adult heart development …

Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy histologically
characterized by the replacement of myocardium by fibrofatty infiltration, cardiomyocyte loss …

Background Desmoplakin (DSP) genetic variants have been reported in arrhythmogenic
cardiomyopathy with particular regard to predominant left ventricular (LV) involvement …

Arrhythmogenic cardiomyopathy (ACM) is a hereditary myocardial disease characterized by
the replacement of the ventricular myocardium with fibrous fatty deposits. ACM is usually …

Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart
muscle disease characterized by fibrofatty replacement of the myocardium and ventricular …

Health is strongly affected by aging and lifespan-modulating interventions, but the molecular
mechanisms of mortality regulation remain unclear. Here, we conducted an RNA-seq …

Arrhythmogenic cardiomyopathy (AC) is a hereditary cardiac disorder characterized by the
gradual replacement of cardiomyocytes with fibrous and adipose tissue, leading to …

Arrhythmogenic cardiomyopathy (ACM) is an inherited myocardial disease at risk of sudden
death. Genetic testing impacts greatly in ACM diagnosis, but gene-disease associations …

Graphical Abstract Curative therapy in AC: outstanding questions. Upper panel: delivery of
CDC-derived EVs seems to attenuate AC in desmoglein-2 mutant mice, thus being …

The familial nonischemic cardiomyopathies are complex disorders of altered cardiac
structure, contractile function, and electrophysiology. They often are caused by mendelian …