Expanding chemistry through in vitro and in vivo biocatalysis

EN Kissman, MB Sosa, DC Millar, EJ Koleski… - Nature, 2024 - nature.com
Living systems contain a vast network of metabolic reactions, providing a wealth of enzymes
and cells as potential biocatalysts for chemical processes. The properties of protein and cell …

The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis

RA Sheldon, D Brady, ML Bode - Chemical science, 2020 - pubs.rsc.org
Enzymes are excellent catalysts that are increasingly being used in industry and academia.
This perspective is primarily aimed at synthetic organic chemists with limited experience …

State-of-the-art biocatalysis

JB Pyser, S Chakrabarty, EO Romero… - ACS central …, 2021 - ACS Publications
The use of enzyme-mediated reactions has transcended ancient food production to the
laboratory synthesis of complex molecules. This evolution has been accelerated by …

Charting the evolution of chemoenzymatic strategies in the syntheses of complex natural products

CN Stout, NM Wasfy, F Chen… - Journal of the American …, 2023 - ACS Publications
Bolstered by recent advances in bioinformatics, genetics, and enzyme engineering, the field
of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This …

Enzymatic late‐stage modifications: better late than never

E Romero, BS Jones, BN Hogg… - Angewandte Chemie …, 2021 - Wiley Online Library
Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

RetroBioCat database: a platform for collaborative curation and automated meta-analysis of biocatalysis data

W Finnigan, M Lubberink, LJ Hepworth, J Citoler… - ACS …, 2023 - ACS Publications
Despite the increasing use of biocatalysis for organic synthesis, there are currently no
databases that adequately capture synthetic biotransformations. The lack of a biocatalysis …

Dearomative logic in natural product total synthesis

CJ Huck, YD Boyko, D Sarlah - Natural product reports, 2022 - pubs.rsc.org
Covering: 2011 to 2022 The natural world is a prolific source of some of the most interesting,
rare, and complex molecules known, harnessing sophisticated biosynthetic machinery …

Enabling broader adoption of biocatalysis in organic chemistry

EO Romero, AT Saucedo, JR Hernández-Meléndez… - JACS Au, 2023 - ACS Publications
Biocatalysis is becoming an increasingly impactful method in contemporary synthetic
chemistry for target molecule synthesis. The selectivity imparted by enzymes has been …

Chemoenzymatic total synthesis of natural products

S Chakrabarty, EO Romero, JB Pyser… - Accounts of chemical …, 2021 - ACS Publications
Conspectus The total synthesis of structurally complex natural products has challenged and
inspired generations of chemists and remains an exciting area of active research. Despite …

Reinvigorating the chiral pool: chemoenzymatic approaches to complex peptides and terpenoids

CN Stout, H Renata - Accounts of chemical research, 2021 - ACS Publications
Conspectus Biocatalytic transformations that leverage the selectivity and efficiency of
enzymes represent powerful tools for the construction of complex natural products. Enabled …