The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

The brain is characterized by heterogeneous patterns of structural connections supporting
unparalleled feats of cognition and a wide range of behaviours. New non-invasive imaging …

The endoplasmic reticulum (ER) and mitochondria accumulate Ca2+ within their lumens to
regulate numerous cell functions. However, determining the dynamics of intraorganellar …

Microglia, the brain resident macrophages, critically shape forebrain neuronal circuits.
However, their precise function in the cerebellum is unknown. Here we show that human …

We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to
the CA1 pyramidal cells of the hippocampus by using a new and general method that allows …

Two-photon calcium imaging is a powerful means for monitoring the activity of distinct
neurons in brain tissue in vivo. In the mammalian brain, such imaging studies have been …

Fast excitatory neurotransmission is mediated by activation of synaptic ionotropic glutamate
receptors. In hippocampal slices, we report that stimulation of Schaffer collaterals evokes in …

Astrocytes in the brain form an intimately associated network with neurons. They respond to
neuronal activity and synaptically released glutamate by raising intracellular calcium …

MOST excitatory synaptic connections occur on dendritic spines1. Calcium imaging
experiments have suggested that spines constitute individual calcium compartments2, 3, but …

THE avermectins are a family of macrocyclic lactones used in the control of nematode and
arthropod parasites1. Ivermectin (22, 23-dihydroavermectin Bla) is widely used as an …