Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …

The KCNQ1 ion channel plays critical physiological roles in electrical excitability and K+
recycling in organs including the heart, brain, and gut. Loss of function is relatively common …

Gating of voltage-dependent cation channels involves three general molecular processes:
voltage sensor activation, sensor-pore coupling, and pore opening. KCNQ1 is a voltage …

Ventricular arrhythmia without structural heart disease is an arrhythmic disorder that occurs
in structurally normal heart and no transient or reversible arrhythmia factors, such as …

The IKs channel complex is formed by the co-assembly of Kv7. 1 (KCNQ1), a voltage-gated
potassium channel, with its β-subunit, KCNE1 and the association of numerous accessory …

Voltage-gated potassium 7.1 (Kv7. 1) channel and KCNE1 protein coassembly forms the
slow potassium current IKS that repolarizes the cardiac action potential. The physiological …

Abstract Kv7. 1-Kv7. 5 (KCNQ1–5) K+ channels are voltage-gated K+ channels with major
roles in neurons, muscle cells and epithelia where they underlie physiologically important …

Long QT syndrome type 1 (LQT1) is a subtype of a congenital cardiac syndrome caused by
mutation in the KCNQ1 gene, which encodes the α-subunit of the slow component of …

Advances in next-generation sequencing have been exceptionally valuable for identifying
variants in medically actionable genes. However, for most missense variants there is …