Next generation sequencing is in the process of evolving from a technology used for
research purposes to one which is applied in clinical diagnostics. Recently introduced high …

Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of …

Tuberculosis is second only to COVID-19 as a cause of death from a single infectious agent.
In 2020, almost 10 million people were estimated to have developed tuberculosis and it …

Analyzing whole-genome sequencing data of Mycobacterium tuberculosis complex (MTBC)
isolates in a standardized workflow enables both comprehensive antibiotic resistance …

Objectives To develop a robust phenotypic antimicrobial susceptibility testing (AST) method
with a correctly set breakpoint for pretomanid (Pa), the most recently approved anti …

Page 1 Catalogue of mutations in Mycobacterium tuberculosis complex and their
association with drug resistance Second edition Page 2 Page 3 Catalogue of mutations in …

Drug-resistant tuberculosis is a substantial health-care concern worldwide. Despite culture-
based methods being considered the gold standard for drug susceptibility testing, molecular …

There is increasing evidence that human movement facilitates the global spread of resistant
bacteria and antimicrobial resistance (AMR) genes. We systematically reviewed the …

Background Tracking recent transmission is a vital part of controlling widespread pathogens
such as Mycobacterium tuberculosis. Multiple methods with specific performance …

Quantifying pathogen transmission in multi-host systems is difficult, as exemplified in bovine
tuberculosis (bTB) systems, but is crucial for control. The agent of bTB, Mycobacterium bovis …