Cancer comprises a group of heterogeneous diseases encompassing high rates of
morbidity and mortality. Heterogeneity, which is a hallmark of cancer, is one of the main …

Experimental evidence that RNA virus populations consist of distributions of mutant
genomes, termed quasispecies, was first published 31 years ago. This work provided the …

Phase transitions--changes between different states of organization in a complex system--
have long helped to explain physics concepts, such as why water freezes into a solid or …

Cancer stem cells (CSCs) drive tumor progression, metastases, treatment resistance, and
recurrence. Understanding CSC kinetics and interaction with their nonstem counterparts …

Here we show that a subpopulation of MCF-7 breast cancer cells which stains pale to
Toluidine Blue (Light Cells-LCs), is endowed with features of CSCs. LCs give rise to self …

Tumors are appreciated to be an intrinsically heterogeneous population of cells with varying
proliferation capacities and tumorigenic potentials. As a central tenet of the so-called cancer …

We review the origins of the quasispecies concept and its relevance for RNA virus evolution,
viral pathogenesis and antiviral treatment strategies. We emphasize a critical point of …

Cancer stem cells (CSCs) are key in understanding tumor growth and tumor progression. A
counterintuitive effect of CSCs is the so-called tumor growth paradox: the effect where a …

RNA genetic elements include many important animal and plant pathogens. They share
high mutability, a trait that has multiple implications for the interactions with their host …

Under the cancer stem cell (CSC) hypothesis, sustained metastatic growth requires the
dissemination of a CSC from the primary tumour followed by its re-establishment in a …