Fanconi anemia (FA), a chromosomal instability syndrome, is caused by inherited
pathogenic variants in any of 22 FANC genes, which cooperate in the FA/BRCA pathway …

The inherited bone marrow failure syndromes (IBMFS) typically present with significant
cytopenias in at least one haematopoietic cell lineage that may progress to pancytopenia …

Gene regulatory networks (GRNs) process important information in developmental biology
and biomedicine. A key knowledge gap concerns how their responses change over time …

Quantitative systems pharmacology (QSP) is an emerging discipline that aims to discover
how drugs modulate the dynamics of biological components in molecular and cellular …

Double strand break (DSB) repair is critical to maintaining the integrity of the genome. DSB
repair deficiency underlies multiple pathologies, including cancer, chromosome instability …

Robustness and evolvability are essential properties to the evolution of biological networks.
To determine if a biological network is robust and/or evolvable, it is required to compare its …

In most cases of primary ovarian insufficiency (POI), the cause of the depletion of ovarian
follicles is unknown. Fanconi anemia (FA) proteins are known to play important roles in …

DNA is constantly exposed to endogenous and exogenous mutagenic stimuli that are
capable of producing diverse lesions. In order to protect the integrity of the genetic material …

Cases of more than three primary cancers are very rare. This study analyzed the genetic
susceptibility of gene polymorphisms in three patients with multiple primary malignant …

Fanconi Anaemia (FA) is an autosomal recessive disorder characterised by defects in DNA
repair, associated with chromosomal instability and cellular hypersensitivity to DNA cross …