There is increasing evidence regarding the importance of allergic sensitization through the
skin. In this review, we provide an overview of the atopic march and immune mechanism …

Food allergy is a major public health issue with growing prevalence in the urbanized world
and significant impact on the lives of allergic patients and their families. Research into the …

IgE-mediated food allergies are caused by adverse immunologic responses to food proteins.
Allergic reactions may present locally in different tissues such as skin, gastrointestinal and …

The achievement of long‐lasting, safe treatments for food allergy is dependent on the
understanding of the immunological basis of food allergy. Accurate diagnosis is essential for …

IgE-mediated food allergy affects 6–8% of the population in the United States. Type 2
immune responses are central to the pathogenesis of food allergy, but type 2 CD4+ T cell …

Background Allergen-specific IL-4+ and IL-13+ CD4+ cells (type 2 cells) are essential for
helping B cells to class-switch to IgE and establishing an allergic milieu in the …

IgE-mediated peanut allergic is common, often serious, and usually lifelong. Not all
individuals who produce peanut-specific IgE will react upon consumption of peanut and can …

Food allergy affects an estimated 8% of children in the United States. Oral immunotherapy
(OIT) is a recently approved treatment, with outcomes ranging from sustained tolerance to …

IgE-mediated food allergy (IgE-FA) occurs due to a breakdown in immune tolerance that
leads to a detrimental type 2 helper T cell (TH2) adaptive immune response. While the …

Antigen‐specific T lymphocytes are the central regulators of tolerance versus immune
pathology against otherwise innocuous antigens and key targets of antigen‐specific immune …