Origins and molecular effects of hypoxia in cancer
S Rey-Keim, L Schito - Seminars in Cancer Biology, 2024 - Elsevier
Hypoxia (insufficient O 2) is a pivotal factor in cancer progression, triggering genetic,
transcriptional, translational and epigenetic adaptations associated to therapy resistance …
transcriptional, translational and epigenetic adaptations associated to therapy resistance …
Oxygen control in cell culture–your cells may not be experiencing what you think!
Abstract Oxygen (O 2)-controlled cell culture has been pivotal in studying mammalian
mechanisms of O 2 sensing, regulation, and utilization. We posit, however, that O 2 …
mechanisms of O 2 sensing, regulation, and utilization. We posit, however, that O 2 …
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells
The in vitro oxygen microenvironment profoundly affects the capacity of cell cultures to
model physiological and pathophysiological states. Cell culture is often considered to be …
model physiological and pathophysiological states. Cell culture is often considered to be …
Pancancer analysis of NDUFA4L2 with focused role in tumor progression and metastasis of colon adenocarcinoma
R Zhou, Z Sun, R Zhou, M Wang, Q Zhuo, X Deng… - Medical Oncology, 2024 - Springer
Colon adenocarcinoma (COAD) is a prevalent gastrointestinal malignant disease with a
high mortality rate, and identification of novel prognostic biomarkers and therapeutic targets …
high mortality rate, and identification of novel prognostic biomarkers and therapeutic targets …
Tumor microenvironment-like conditions alter pancreatic cancer cell metabolism and behavior
GL Gardner, JA Stuart - American Journal of Physiology …, 2024 - journals.physiology.org
The tumor microenvironment is complex and dynamic, characterized by poor
vascularization, limited nutrient availability, hypoxia, and an acidic pH. This environment …
vascularization, limited nutrient availability, hypoxia, and an acidic pH. This environment …
Investigating the Importance of Physiological Cell Culture Conditions in Modeling Cancer Metabolism and Metabolic Reprogramming
G Gardner - 2024 - dr.library.brocku.ca
Standard cell culture conditions do not mimic the physiological environment of cancer cells.
Traditional culture media contain metabolites at concentrations that far exceed conditions …
Traditional culture media contain metabolites at concentrations that far exceed conditions …