Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

DNA methylation is known to be abnormal in all forms of cancer, but it is not really
understood how this occurs and what is its role in tumorigenesis. In this review, we take a …

Super-enhancers (SEs) are cell-specific DNA cis-regulatory elements that can supervise the
transcriptional regulation processes of downstream genes. SEdb 2.0 (http://www. licpathway …

In the mammalian genome, DNA methylation is an epigenetic mechanism involving the
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …

Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …

In many organisms, the methylation of cytosine in DNA has a key role in silencing'parasitic'
DNA elements, regulating transcription and establishing cellular identity. The recent …

DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …

Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …

A succession of technological advances over the past decade have enabled researchers to
chart maps of histone modifications and related chromatin structures with increasing …