The generation of haploid gametes by meiosis is a highly conserved process for sexually
reproducing organisms that, in almost all cases, involves the extensive breakage of …

In mammalian male meiosis, the heterologous X and Y chromosomes remain unsynapsed
and, as a result, are subject to meiotic sex chromosome inactivation (MSCI). MSCI is …

The piRNA machinery is known for its role in mediating epigenetic silencing of transposons.
Recent studies suggest that this function also involves piRNA-guided cleavage of …

Centrosomes are the canonical microtubule organizing centers (MTOCs) of most
mammalian cells, including spermatocytes. Centrosomes comprise a centriole pair within a …

In most taxa, halving of chromosome numbers during meiosis requires that homologous
chromosomes (homologues) pair and form crossovers. Crossovers emerge from the …

Precise control of chromosome dynamics during meiosis is critical for fertility. A gametocyte
undergoing meiosis coordinates formation of the synaptonemal complex (SC) to promote …

Meiotic crossovers (COs) are crucial for ensuring accurate homologous chromosome
segregation during meiosis I. Because the double-strand breaks (DSBs) that initiate meiotic …

Testicular germ cell tumors (TGCTs) are among the most responsive solid cancers to
conventional chemotherapy. To elucidate the underlying mechanisms, we developed a …

Background Fusobacterium nucleatum (F. nucleatum) is one of the key tumorigenic bacteria
in colorectal cancer (CRC), yet how F. nucleatum is involved in colorectal cancer …

The establishment of bipolar spindles during meiotic divisions ensures faithful chromosome
segregation to prevent gamete aneuploidy. We analyzed centriole duplication, as well as …