Most viral pathogens in humans have animal origins and arose through cross-species
transmission. Over the past 50 years, several viruses, including Ebola virus, Marburg virus …

Despite the recognized excellence of virology and bioinformatics, these two communities
have interacted surprisingly sporadically, aside from some pioneering work on HIV-1 and …

Background In recent years, massively parallel complementary DNA sequencing (RNA
sequencing [RNA-Seq]) has emerged as a fast, cost-effective, and robust technology to …

Bats harbor many viruses asymptomatically, including several notorious for causing extreme
virulence in humans. To identify differences between antiviral mechanisms in humans and …

Ebola virus (EBOV) causes epidemics with high mortality yet remains understudied due to
the challenge of experimentation in high-containment and outbreak settings. Here, we used …

Bats host a large number of zoonotic viruses, including several viruses that are highly
pathogenic to other mammals. The mechanisms underlying this rich viral diversity are …

ABSTRACT Marburg (MARV) and Ebola (EBOV) viruses are zoonotic pathogens that cause
severe hemorrhagic fever in humans. The natural reservoir of MARV is the Egyptian rousette …

Ebola virus (EBOV) infections are characterized by a pronounced lymphopenia that is highly
correlative with fatalities. However, the mechanisms leading to T-cell depletion remain …

Alteration of host cell splicing is a common feature of many viral infections which is
underappreciated because of the complexity and technical difficulty of studying alternative …

Engineered liver systems come in a variety of platform models, from 2-dimensional
cocultures of primary human hepatocytes and stem cell–derived progeny, to 3-dimensional …