Understanding the organizational logic of neural circuits requires deciphering the biological
basis of neuronal diversity and identity, but there is no consensus on how neuron types …

There is a need for new therapeutic targets with which to prevent Alzheimer's disease (AD),
a major contributor to aging-related cognitive decline. Here we report the construction and …

Dispersion of tumors throughout the body is a neoplastic process responsible for the vast
majority of deaths from cancer. Despite disseminating to distant organs as malignant scouts …

Establishing the molecular diversity of cell types is crucial for the study of the nervous
system. We compiled a cross-laboratory database of mouse brain cell type-specific …

The coupling between Ca 2+ channels and release sensors is a key factor defining the
signaling properties of a synapse. However, the coupling nanotopography at many …

Sensory integration difficulties have been reported in autism, but their underlying brain-
circuit mechanisms are underexplored. Using five autism-related mouse models …

Human mutations in CNTNAP2 are associated with an array of neuropsychiatric and
neurological syndromes, including speech and language disorders, epilepsy, and autism …

Dominant spinocerebellar ataxias (SCAs) constitute a large group of phenotypically and
genetically heterogeneous disorders that mainly present with dysfunction of the cerebellum …

We consider the problem of estimating common community structures in multi-layer
stochastic block models, where each single layer may not have sufficient signal strength to …

Summary Synaptotagmin 7 (Syt7) is thought to be a Ca 2+ sensor that mediates
asynchronous transmitter release and facilitation at synapses. However, Syt7 is strongly …