The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …

Abstract β-thalassemia is a hereditary hematological disease caused by over 350 mutations
in the β-globin gene (HBB). Identifying the genetic variants affecting fetal hemoglobin (HbF) …

Hemoglobinopathies are among the most common monogenic diseases worldwide.
Approximately 1–5% of the global population are carriers for a genetic thalassemia …

Bone morphogenetic proteins (BMPs) are secreted cytokines that control the fate and
function of many different cell types. They exert their cellular responses via heteromeric …

Muscle wasting disease indications are among the most debilitating and often deadly
noncommunicable disease states. As a comorbidity, muscle wasting is associated with …

Luspatercept is an activin receptor ligand trap that has been shown to enhance late-stage
erythropoiesis in animal models of β-thalassemia. A multicenter, international, phase 2 dose …

Luspatercept (Reblozyl) was recently approved for treating patients with transfusion-
dependent lower-risk myelodysplastic syndrome (MDS) with ring sideroblasts (RS) and/or …

Chimeric antigen receptor (CAR) T cell therapies are medical breakthroughs in cancer
treatment. However, treatment failure is often caused by CAR T cell dysfunction. Additional …

Simple Summary Tumor immune evasion is one of the hallmarks of tumor progression that
enables tumor growth despite the activity of the host immune system. It is mediated by …

Introduction Activin A is involved in the regulation of a surprisingly broad number of
processes that are relevant for cancer development and treatment; it is implicated in cell …