[HTML][HTML] How different viruses perturb host cellular machinery via short linear motifs
The virus interacts with its hosts by developing protein-protein interactions. Most viruses
employ protein interactions to imitate the host protein: A viral protein with the same amino …
employ protein interactions to imitate the host protein: A viral protein with the same amino …
Protein structure–function continuum model: Emerging nexuses between specificity, evolution, and structure
MN Gupta, VN Uversky - Protein Science, 2024 - Wiley Online Library
The rationale for replacing the old binary of structure–function with the trinity of structure,
disorder, and function has gained considerable ground in recent years. A continuum model …
disorder, and function has gained considerable ground in recent years. A continuum model …
Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions.
Studies of motif-mediated interactions therefore provide insight into virus-host …
Studies of motif-mediated interactions therefore provide insight into virus-host …
Rapidly evolving viral motifs mostly target biophysically constrained binding pockets of host proteins
Evolutionary changes in host-virus interactions can alter the course of infection, but the
biophysical and regulatory constraints that shape interface evolution remain largely …
biophysical and regulatory constraints that shape interface evolution remain largely …
Prediction of motif-mediated viral mimicry through the integration of host–pathogen interactions
One of the mechanisms viruses use in hijacking host cellular machinery is mimicking Short
Linear Motifs (SLiMs) in host proteins to maintain their life cycle inside host cells. In the face …
Linear Motifs (SLiMs) in host proteins to maintain their life cycle inside host cells. In the face …
The flexible, extended coil of the PDZ-Binding motif of the three deadly human coronavirus E proteins plays a role in pathogenicity
The less virulent human (h) coronaviruses (CoVs) 229E, NL63, OC43, and HKU1 cause
mild, self-limiting respiratory tract infections, while the more virulent SARS-CoV-1, MERS …
mild, self-limiting respiratory tract infections, while the more virulent SARS-CoV-1, MERS …
Molecular mimicry of host short linear motif-mediated interactions utilised by viruses for entry
S Goswami, D Samanta, K Duraivelan - Molecular Biology Reports, 2023 - Springer
Viruses are obligate intracellular parasites that depend on host cellular machinery for
performing even basic biological functions. One of the many ways they achieve this is …
performing even basic biological functions. One of the many ways they achieve this is …
ORF45, a multifunctional immediate early and tegument protein of KSHV
Kaposi sarcoma‐associated herpesvirus (KSHV) is the etiological agent of several human
diseases, including Kaposi sarcoma, primary effusion lymphoma, and a subset of …
diseases, including Kaposi sarcoma, primary effusion lymphoma, and a subset of …
Comparative analysis of structural features in SLiMs from eukaryotes, bacteria, and viruses with importance for host-pathogen interactions
H Elkhaligy, CA Balbin, J Siltberg-Liberles - Pathogens, 2022 - mdpi.com
Protein-protein interactions drive functions in eukaryotes that can be described by short
linear motifs (SLiMs). Conservation of SLiMs help illuminate functional SLiMs in eukaryotic …
linear motifs (SLiMs). Conservation of SLiMs help illuminate functional SLiMs in eukaryotic …
[PDF][PDF] The Flexible, Extended Coil of the PDZ-Binding Motif of the Three Deadly Human Coronavirus E Proteins Plays a Role in Pathogenicity. Viruses 2022, 14, 1707
D Schoeman, R Cloete, BC Fielding - 2022 - researchgate.net
The less virulent human (h) coronaviruses (CoVs) 229E, NL63, OC43, and HKU1 cause
mild, self-limiting respiratory tract infections, while the more virulent SARS-CoV-1, MERS …
mild, self-limiting respiratory tract infections, while the more virulent SARS-CoV-1, MERS …