Clinical utility of circulating tumor DNA as a response and follow-up marker in cancer therapy

PA Boonstra, TT Wind, M van Kruchten… - Cancer and Metastasis …, 2020 - Springer
Response evaluation for cancer treatment consists primarily of clinical and radiological
assessments. In addition, a limited number of serum biomarkers that assess treatment …

Diagnostic and prognostic impact of cell-free DNA in human cancers: Systematic review

K Cervena, P Vodicka, V Vymetalkova - Mutation Research/Reviews in …, 2019 - Elsevier
The development of minimally invasive and low-cost assay enabling early diagnosis,
treatment response and prognosis in cancer patients may provide a promising alternative to …

BPTF Drives Gastric Cancer Resistance to EGFR Inhibitor by Epigenetically Regulating the C‐MYC/PLCG1/Perk Axis

F Li, J Yu, T Pan, H Feng, J Li, B Yu, Z Fan… - Advanced …, 2023 - Wiley Online Library
Erlotinib, an EGFR tyrosine kinase inhibitor, is used for treating patients with cancer
exhibiting EGFR overexpression or mutation. However, the response rate of erlotinib is low …

Identification of microRNAs that promote erlotinib resistance in non-small cell lung cancer

AS Pal, M Bains, A Agredo, AL Kasinski - Biochemical pharmacology, 2021 - Elsevier
Lung cancer is the leading cause of cancer-related deaths, demanding improvement in
current treatment modalities to reduce the mortality rates. Lung cancer is divided into two …

Study on the prognosis, immune and drug resistance of m6A-related genes in lung cancer

Y Yang, Z Qian, M Feng, W Liao, Q Wu, F Wen, Q Li - BMC bioinformatics, 2022 - Springer
Background Few studies have demonstrated that the relationship between m6A-related
genes and the prognosis, tumor microenvironment and drug resistance of LC. Methods The …

[HTML][HTML] Premetastatic shifts of endogenous and exogenous mutational processes support consolidative therapy in EGFR-driven lung adenocarcinoma

JN Fisk, AR Mahal, A Dornburg, SG Gaffney, S Aneja… - Cancer letters, 2022 - Elsevier
The progression of cancer is an evolutionary process that is challenging to monitor between
sampling timepoints. However, investigation of cancer evolution over specific time periods is …

The Dynamic Use of EGFR Mutation Analysis in Cell‐Free DNA as a Follow‐Up Biomarker during Different Treatment Lines in Non‐Small‐Cell Lung Cancer Patients

M Macías, E Alegre, G Alkorta-Aranburu… - Disease …, 2019 - Wiley Online Library
Epidermal growth factor receptor (EGFR) mutational testing in advanced non‐small‐cell
lung cancer (NSCLC) is usually performed in tumor tissue, although cfDNA (cell‐free DNA) …

Clinicopathological and prognostic implications of EGFR mutations subtypes in Moroccan non-small cell lung cancer patients: A first report

S Boukansa, I Mouhrach, F El Agy, S El Bardai… - Plos one, 2024 - journals.plos.org
Background Non-small cell lung cancer (NSCLC) remains a significant global health
concern, with EGFR mutations playing a pivotal role in guiding treatment decisions. This …

Generation of osimertinib-resistant cells from epidermal growth factor receptor L858R/T790M mutant non-small cell lung carcinoma cell line

ND Verusingam, YC Chen, HF Lin, CY Liu… - Journal of the …, 2021 - journals.lww.com
Background: Lung cancer contributes to high cancer mortality worldwide with 80% of total
cases diagnosed as non-small cell lung cancer (NSCLC). Epidermal growth factor receptor …

Screening system for epidermal growth factor receptor mutation detection in cytology cell‐free DNA of cerebrospinal fluid based on assured sample quality

A Kawahara, H Abe, K Murata, H Ishii, K Azuma… - …, 2019 - Wiley Online Library
Background The cobas® epidermal growth factor receptor (EGFR) Mutation Test v2
designed for cell‐free DNA (cf DNA) is approved as a companion diagnostic for osimertinib …