The existence of cellular heterogeneity and its central relevance to biological phenomena
provides a strong rationale for a need for analytical methods that enable analysis at the …

Signalling through the B cell receptor (BCR) is central to the development and maintenance
of B cells. In light of the numerous proliferative and survival pathways activated downstream …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

B cells are capable of a wide range of effector functions including antibody secretion,
antigen presentation, cytokine production, and generation of immunological memory. A …

Flow cytometry is an essential tool for dissecting the functional complexity of hematopoiesis.
We used single-cell “mass cytometry” to examine healthy human bone marrow, measuring …

Elucidation and examination of cellular subpopulations that display condition-specific
behavior can play a critical contributory role in understanding disease mechanism, as well …

Follicular lymphoma (FL) is incurable with conventional therapies and has a clinical course
typified by multiple relapses after therapy. These tumors are genetically characterized by B …

Recent studies have revealed extensive genetic and non-genetic variation across different
geographical regions of a tumor or throughout different stages of tumor progression, which is …

The hallmark t (14; 18)(q32; q21) in follicular lymphoma (FL) results in constitutive
overexpression of the BCL2 protein, allowing B cells to abrogate the default germinal center …