The dramatic recent advances in molecular biology, which have opened a new era in
medicine and biotechnology, rely on improved techniques to study large molecules …

This Review addresses methods for obtaining sequence information directly from
unamplified genomic length DNA. Our generic starting point is a large piece of DNA that …

The self-diffusion coefficient of a series of DNA fragments ranging from 280 to 5386 bases
has been measured by fluorescence recovery after photobleaching after thermal …

The application of microfluidics to biotechnology is an exciting new area that has already
begun to revolutionize how researchers study and manipulate macromolecules like DNA …

The racemic and meso diastereomers of an electron-rich binucleating tetraphosphine ligand
have been used to prepare homobimetallic rhodium norbornadiene complexes. The racemic …

The configurations and dynamics of a polymer ring (R) inside a strongly crosslinked polymer
gel (G) are discussed and compared to those of linear (L) and branched (B) polymers in G. R …

Picking up at the conclusion of Viovy's review of the physics of gel electrophoresis [J.-L.
Viovy, Rev. Mod. Phys. 72, 813 (2000) 10.1103/RevModPhys. 72.813], this review …

Abstract Theory and numerical simulations play a major role in the development of improved
and novel separation methods. In some cases, computer simulations predict counterintuitive …

The electrophoresis of long polyelectrolytes is considered theoretically, with special
attention to duplex DNA. We first discuss quantitative approaches to determine …

An extensive series of experiments has been performed to study the mobility of DNA
fragments ranging in size from 2.0 to 48.5 kilobose pairs. By varying the agarose …