Introduction: Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a key
role in diverse gene expressions responsible for protection against oxidative stress and …

The surge of scientific interest in the discovery of Nuclear Factor Erythroid 2 (NFE2)-Related
Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic …

Abstract Leishmaniasis is a Neglected Tropical Diseases caused by protozoan parasites of
the genus Leishmania. It is a major health problem in many tropical and subtropical regions …

This study was aimed at investigating the leishmanicidal and immunomodulatory of oregano
essential oil (OEO) from Origanum vulgare on experimental Leishmania amazonensis …

Treatment of leishmaniasis is a challenging subject. Although available, chemotherapy is
limited, presenting toxicity and adverse effects. New drugs with antileishmanial activity are …

Leishmaniasis is a neglected tropical disease caused by protozoa of the genus Leishmania.
The first-line treatment of this disease is still based on pentavalent antimonial drugs that …

Heme oxygenase (HO-1) mediates the enzymatic cleavage of heme, a molecule with
proinflammatory and prooxidant properties. HO-1 activity deeply impacts host capacity to …

A chromone-peptidyl hybrids series was synthesised and rationally repurposed towards
identification of potential antileishmanial hits against visceral leishmaniasis. Three hybrids …

The Leishmaniasis treatment currently available involves some difficulties, such as high
toxicity, variable efficacy, high cost, therefore, it is crucial to search for new therapeutic …

American tegumentary leishmaniasis, a zoonotic disease caused by the Leishmania genus,
poses significant challenges in treatment, including administration difficulty, low efficacy, and …