In the face of increasing bacterial resistance to antibiotics currently in use, the search for
new antimicrobial agents has received a boost in recent years, with natural products playing …

The rising burden of antimicrobial resistance and increasing infectious disease outbreaks,
including the recent COVID-19 pandemic, has led to a growing demand for the development …

Berberine is an alkaloid of the protoberberine type used in traditional oriental medicine. Its
biological activities include documented antibacterial properties against a wide variety of …

Postgenomics drug development is undergoing major transformation in the age of multi-
omics studies and drug repositioning. Rather than applications solely in personalized …

A plethora of natural products emerges as attractive molecules in the struggle against
antibiotic resistance. These molecules impose their bioactivities not only alone but also in …

Berberine is a plant-derived alkaloid possessing antimicrobial activity; unfortunately, its
efflux through multidrug resistance pumps reduces its efficacy. Cellular life span of …

Historically, plants with a wide range of natural products they possess have long served as
important sources of therapeutical agents. Unfortunately, progress in the construction of …

Discovery of new antibacterials with novel mechanisms is important to counteract the
ingenious resistance mechanisms of bacteria. In this connection, omics-guided drug …

The affinity of ß-lactamase inhibitory protein (BLIP) for TEM-1 ß-lactamase has raised hopes
in the challenge of protein-based inhibitor discovery for ß-lactamase-mediated antibiotic …

New global regulations and greater ethical conscience lead to stronger controls on the use
of vertebrates in pre-clinical studies. To overcome the significant costs and time required to …